Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
X-linked myotubular myopathy (XLMTM) is a severe muscle disease with no effective treatment. Here, the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model of the disease, at least in part by normalizing expression of the disease modifier proteins D...
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Bibliographic Details
| Main Authors: |
Elinam Gayi,
Laurence A. Neff,
Xènia Massana Muñoz,
Hesham M. Ismail,
Marta Sierra,
Thomas Mercier,
Laurent A. Décosterd,
Jocelyn Laporte,
Belinda S. Cowling,
Olivier M. Dorchies,
Leonardo Scapozza |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07058-4
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