Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer
Although a quadruple mass analyzer and an ion trap mass analyzer have complementary analytical features, they usually have different geometries, operational modes, and electronic control systems. As a continuous effort to extend its coverage, both quadrupole and ion trap operation modes were realize...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/22/7640 |
| _version_ | 1797458171594276864 |
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| author | Chaohong Feng Siyu Liu Ting Jiang Wei Xu |
| author_facet | Chaohong Feng Siyu Liu Ting Jiang Wei Xu |
| author_sort | Chaohong Feng |
| collection | DOAJ |
| description | Although a quadruple mass analyzer and an ion trap mass analyzer have complementary analytical features, they usually have different geometries, operational modes, and electronic control systems. As a continuous effort to extend its coverage, both quadrupole and ion trap operation modes were realized on a “brick” miniature mass spectrometer with a single mass analyzer. In the quadrupole operation mode, low-mass ions ranging from 31 to 502 Th can be analyzed. On the other hand, the ion trap mode can be utilized to cover ions with higher mass to charge ratios (up to 922 Th), as well as performing tandem mass spectrometry. To realize the multiplexing of both operation modes, a printed circuit board (PCB)-based multi-electrode quadrupole–ion trap mass analyzer was designed and integrated in the system. To cover both volatile and non-volatile molecules, two ionization sources were also implemented, including a nano electrospray ionization source and an in-vacuum plasma ionization source. Performances of the instrument operated in these two modes were characterized, such as mass resolution, sensitivity, and mass range. Results demonstrate that the combination of the quadrupole and ion trap operation modes can provide new capabilities when solving analytical problems. |
| first_indexed | 2024-03-09T16:34:12Z |
| format | Article |
| id | doaj.art-55e37dcae442440b83bcf68b97032c5e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:34:12Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-55e37dcae442440b83bcf68b97032c5e2023-11-24T14:58:31ZengMDPI AGMolecules1420-30492023-11-012822764010.3390/molecules28227640Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass SpectrometerChaohong Feng0Siyu Liu1Ting Jiang2Wei Xu3School of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaAlthough a quadruple mass analyzer and an ion trap mass analyzer have complementary analytical features, they usually have different geometries, operational modes, and electronic control systems. As a continuous effort to extend its coverage, both quadrupole and ion trap operation modes were realized on a “brick” miniature mass spectrometer with a single mass analyzer. In the quadrupole operation mode, low-mass ions ranging from 31 to 502 Th can be analyzed. On the other hand, the ion trap mode can be utilized to cover ions with higher mass to charge ratios (up to 922 Th), as well as performing tandem mass spectrometry. To realize the multiplexing of both operation modes, a printed circuit board (PCB)-based multi-electrode quadrupole–ion trap mass analyzer was designed and integrated in the system. To cover both volatile and non-volatile molecules, two ionization sources were also implemented, including a nano electrospray ionization source and an in-vacuum plasma ionization source. Performances of the instrument operated in these two modes were characterized, such as mass resolution, sensitivity, and mass range. Results demonstrate that the combination of the quadrupole and ion trap operation modes can provide new capabilities when solving analytical problems.https://www.mdpi.com/1420-3049/28/22/7640ion trapquadrupoleminiature mass spectrometerPCB-based multi-electrode mass analyzer |
| spellingShingle | Chaohong Feng Siyu Liu Ting Jiang Wei Xu Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer Molecules ion trap quadrupole miniature mass spectrometer PCB-based multi-electrode mass analyzer |
| title | Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer |
| title_full | Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer |
| title_fullStr | Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer |
| title_full_unstemmed | Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer |
| title_short | Multiplexing Quadrupole and Ion Trap Operation Modes on a “Brick” Miniature Mass Spectrometer |
| title_sort | multiplexing quadrupole and ion trap operation modes on a brick miniature mass spectrometer |
| topic | ion trap quadrupole miniature mass spectrometer PCB-based multi-electrode mass analyzer |
| url | https://www.mdpi.com/1420-3049/28/22/7640 |
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