ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications
Cell death is a fundamental pathophysiological process in human disease. The discovery of necroptosis, a form of regulated necrosis that is induced by the activation of death receptors and formation of necrosome, represents a major breakthrough in the field of cell death in the past decade. Z-DNA-bi...
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/1/52 |
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| author | Xin-yu Chen Ying-hong Dai Xin-xing Wan Xi-min Hu Wen-juan Zhao Xiao-xia Ban Hao Wan Kun Huang Qi Zhang Kun Xiong |
| author_facet | Xin-yu Chen Ying-hong Dai Xin-xing Wan Xi-min Hu Wen-juan Zhao Xiao-xia Ban Hao Wan Kun Huang Qi Zhang Kun Xiong |
| author_sort | Xin-yu Chen |
| collection | DOAJ |
| description | Cell death is a fundamental pathophysiological process in human disease. The discovery of necroptosis, a form of regulated necrosis that is induced by the activation of death receptors and formation of necrosome, represents a major breakthrough in the field of cell death in the past decade. Z-DNA-binding protein (ZBP1) is an interferon (IFN)-inducing protein, initially reported as a double-stranded DNA (dsDNA) sensor, which induces an innate inflammatory response. Recently, ZBP1 was identified as an important sensor of necroptosis during virus infection. It connects viral nucleic acid and receptor-interacting protein kinase 3 (RIPK3) via two domains and induces the formation of a necrosome. Recent studies have also reported that ZBP1 induces necroptosis in non-viral infections and mediates necrotic signal transduction by a unique mechanism. This review highlights the discovery of ZBP1 and its novel findings in necroptosis and provides an insight into its critical role in the crosstalk between different types of cell death, which may represent a new therapeutic option. |
| first_indexed | 2024-03-09T03:30:27Z |
| format | Article |
| id | doaj.art-55e5bb30cf5b41fa8002d668e8233c79 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T03:30:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-55e5bb30cf5b41fa8002d668e8233c792023-12-03T14:56:20ZengMDPI AGMolecules1420-30492022-12-012815210.3390/molecules28010052ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic ImplicationsXin-yu Chen0Ying-hong Dai1Xin-xing Wan2Xi-min Hu3Wen-juan Zhao4Xiao-xia Ban5Hao Wan6Kun Huang7Qi Zhang8Kun Xiong9Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 430013, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaDepartment of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 430013, ChinaCell death is a fundamental pathophysiological process in human disease. The discovery of necroptosis, a form of regulated necrosis that is induced by the activation of death receptors and formation of necrosome, represents a major breakthrough in the field of cell death in the past decade. Z-DNA-binding protein (ZBP1) is an interferon (IFN)-inducing protein, initially reported as a double-stranded DNA (dsDNA) sensor, which induces an innate inflammatory response. Recently, ZBP1 was identified as an important sensor of necroptosis during virus infection. It connects viral nucleic acid and receptor-interacting protein kinase 3 (RIPK3) via two domains and induces the formation of a necrosome. Recent studies have also reported that ZBP1 induces necroptosis in non-viral infections and mediates necrotic signal transduction by a unique mechanism. This review highlights the discovery of ZBP1 and its novel findings in necroptosis and provides an insight into its critical role in the crosstalk between different types of cell death, which may represent a new therapeutic option.https://www.mdpi.com/1420-3049/28/1/52ZBP1PANoptosispyroptosisapoptosisnecroptosis |
| spellingShingle | Xin-yu Chen Ying-hong Dai Xin-xing Wan Xi-min Hu Wen-juan Zhao Xiao-xia Ban Hao Wan Kun Huang Qi Zhang Kun Xiong ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications Molecules ZBP1 PANoptosis pyroptosis apoptosis necroptosis |
| title | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications |
| title_full | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications |
| title_fullStr | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications |
| title_full_unstemmed | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications |
| title_short | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications |
| title_sort | zbp1 mediated necroptosis mechanisms and therapeutic implications |
| topic | ZBP1 PANoptosis pyroptosis apoptosis necroptosis |
| url | https://www.mdpi.com/1420-3049/28/1/52 |
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