Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones ar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13075 |
| _version_ | 1797467982758150144 |
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| author | Ewa Szczurowska Eszter Szánti-Pintér Alena Randáková Jan Jakubík Eva Kudova |
| author_facet | Ewa Szczurowska Eszter Szánti-Pintér Alena Randáková Jan Jakubík Eva Kudova |
| author_sort | Ewa Szczurowska |
| collection | DOAJ |
| description | Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge. |
| first_indexed | 2024-03-09T19:00:31Z |
| format | Article |
| id | doaj.art-55e89d5dab5446babb00af227aef3ed0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:31Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-55e89d5dab5446babb00af227aef3ed02023-11-24T05:02:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211307510.3390/ijms232113075Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive SteroidsEwa Szczurowska0Eszter Szánti-Pintér1Alena Randáková2Jan Jakubík3Eva Kudova4Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Namesti 2, Prague 6, 166 10 Prague, Czech RepublicInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Namesti 2, Prague 6, 166 10 Prague, Czech RepublicInstitute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech RepublicInstitute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech RepublicInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Namesti 2, Prague 6, 166 10 Prague, Czech RepublicMuscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge.https://www.mdpi.com/1422-0067/23/21/13075neurosteroidsneuroactive steroidscholesterolmuscarinic receptorsallosteric modulation |
| spellingShingle | Ewa Szczurowska Eszter Szánti-Pintér Alena Randáková Jan Jakubík Eva Kudova Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids International Journal of Molecular Sciences neurosteroids neuroactive steroids cholesterol muscarinic receptors allosteric modulation |
| title | Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids |
| title_full | Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids |
| title_fullStr | Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids |
| title_full_unstemmed | Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids |
| title_short | Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids |
| title_sort | allosteric modulation of muscarinic receptors by cholesterol neurosteroids and neuroactive steroids |
| topic | neurosteroids neuroactive steroids cholesterol muscarinic receptors allosteric modulation |
| url | https://www.mdpi.com/1422-0067/23/21/13075 |
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