| Summary: | Objective: assessing the association of sequence variants rs8192678, rs1801282, rs9939609, rs7799039 and rs1137101in
PPARGC1A, PPARG2, FTO, LEP and LEPR genes, respectively,with non-alcoholic fatty liver disease (NAFLD) inyounger adults
(18-44 years old) of the Russian Federation.
Materials and Methods. Our case-control study encompassed 100 patients distributed between two groups: Group 1 (cases) with
patients suffering from NAFLD (n=50) andGroup 2 (controls) with individuals without it (n=50). All subjects underwent a
conventional sonography of their liver and shear wave elastography (Aixplorer®, France): both ultrasound examinations
assessed the severity of liver steatosis and fibrosis.
Results. We discovered two sequence variants associated with an increased risk of NAFLD in women: rs9939609 and
rs7799039: A/A rs9939609 genotype (OR 5.33, 95% CI 1.14-24.90,p=0.041) and G/G rs7799039genotype (OR 7.5, 95% CI 1.04-
54.12,p=0.026).
Conclusion.The A/A genotype of the rs9939609 gene in younger women of the Russian population yielded the fivefold increase
in the likelihood of NAFLD, whereas the G/G genotype of the rs7799039 gene resulted in a 7.5-fold likelihood ofNAFLD
occurrence
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