BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase e...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19839-x |
| _version_ | 1818683081519792128 |
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| author | Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti |
| author_facet | Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti |
| author_sort | Marco Segatto |
| collection | DOAJ |
| description | Duchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase expression. |
| first_indexed | 2024-12-17T10:29:04Z |
| format | Article |
| id | doaj.art-55e92e9f04a24679a1d5b129a0da42cf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:29:04Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-55e92e9f04a24679a1d5b129a0da42cf2022-12-21T21:52:35ZengNature PortfolioNature Communications2041-17232020-11-0111111310.1038/s41467-020-19839-xBETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophyMarco Segatto0Roberta Szokoll1Raffaella Fittipaldi2Cinzia Bottino3Lorenzo Nevi4Kamel Mamchaoui5Panagis Filippakopoulos6Giuseppina Caretti7Department of Biosciences, Università degli Studi di MilanoDepartment of Biosciences, Università degli Studi di MilanoDepartment of Biosciences, Università degli Studi di MilanoDepartment of Biosciences, Università degli Studi di MilanoDepartment of Biosciences, Università degli Studi di MilanoSorbonne Université, Inserm, Institut de Myologie, U974, Center for Research in MyologyStructural Genomics Consortium, Old Road Campus Research Building, Nuffield Department of MedicineDepartment of Biosciences, Università degli Studi di MilanoDuchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase expression.https://doi.org/10.1038/s41467-020-19839-x |
| spellingShingle | Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy Nature Communications |
| title | BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy |
| title_full | BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy |
| title_fullStr | BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy |
| title_full_unstemmed | BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy |
| title_short | BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy |
| title_sort | bets inhibition attenuates oxidative stress and preserves muscle integrity in duchenne muscular dystrophy |
| url | https://doi.org/10.1038/s41467-020-19839-x |
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