Diethylstilbestrol and autism
It is acknowledged that diethylstilbestrol (DES), a synthetic diphenol with powerful estrogenic properties, causes structural anomalies of the reproductive tract and increases the risk of cancer and genital malformations in children and grandchildren of mothers treated during pregnancy. Conversely,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1034959/full |
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| author | Marie-Odile Soyer-Gobillard Marie-Odile Soyer-Gobillard Laura Gaspari Laura Gaspari Laura Gaspari Philippe Courtet Philippe Courtet Charles Sultan |
| author_facet | Marie-Odile Soyer-Gobillard Marie-Odile Soyer-Gobillard Laura Gaspari Laura Gaspari Laura Gaspari Philippe Courtet Philippe Courtet Charles Sultan |
| author_sort | Marie-Odile Soyer-Gobillard |
| collection | DOAJ |
| description | It is acknowledged that diethylstilbestrol (DES), a synthetic diphenol with powerful estrogenic properties, causes structural anomalies of the reproductive tract and increases the risk of cancer and genital malformations in children and grandchildren of mothers treated during pregnancy. Conversely, data on DES effects on neurodevelopment and psychiatric disorders in in-utero exposed children and their descendants are rare, especially concerning Autism Spectrum Disorders (ASD). Recent studies presented in this review strengthen the hypothesis that in-utero exposure to DES and also other synthetic estrogens and progestogens, which all are endocrine disruptors, contributes to the pathogenesis of psychiatric disorders, especially ASD. A large epidemiological study in the USA in 2010 reported severe depression in in-utero exposed children (n=1,612), and a French cohort study (n=1,002 in-utero DES exposed children) in 2016 found mainly bipolar disorders, schizophrenia, major depression, suicide attempts, and suicide. Few publications described ASD in in-utero exposed children, mainly a Danish cohort study and a large Chinese epidemiological study. Molecular studies on endocrine disruptors demonstrated the transgenerational induction of diseases and DES epigenetic impact (DNA methylation changes) at two genes implicated in neurodevelopment (ZFP57 and ADAM TS9). We recently described in an informative family, somatic and psychiatric disorders in four generations, particularly ASD in boys of the third and fourth generation. These data show that the principle of precaution must be retained for the protection of future generations: women (pregnant or not) should be extremely vigilant about synthetic hormones. |
| first_indexed | 2024-04-11T06:55:41Z |
| format | Article |
| id | doaj.art-55e9e72fd6a04f579f394d0278afc5e5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T06:55:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-55e9e72fd6a04f579f394d0278afc5e52022-12-22T04:39:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10349591034959Diethylstilbestrol and autismMarie-Odile Soyer-Gobillard0Marie-Odile Soyer-Gobillard1Laura Gaspari2Laura Gaspari3Laura Gaspari4Philippe Courtet5Philippe Courtet6Charles Sultan7Univ Sorbonne, Centre National de la Recherche Scientifique (CNRS), Paris, FranceAssociation Halte aux HORmones Artificielles pour les GrossessES (Hhorages)-France, Perpignan, FranceCentre Hospitalier Universitaire (CHU) Montpellier: Univ Montpellier, Unité d’Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie, Montpellier, FranceCentre Hospitalier Universitaire (CHU) Montpellier: Univ Montpellier, Centre de Référence Maladies Rares du Développement Génital, Constitutif Sud, Hôpital Lapeyronie, Montpellier, FranceUniv Montpellier, Institut National de la Santé et de la Recherche Médicale (Inserm) 1203, Développement Embryonnaire Fertilité Environnement, Montpellier, FranceInstitut de Génomique Fonctionnelle (IGF), Univ. Montpellier, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Montpellier, FranceDepartment of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier, FranceCentre Hospitalier Universitaire (CHU) Montpellier: Univ Montpellier, Unité d’Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie, Montpellier, FranceIt is acknowledged that diethylstilbestrol (DES), a synthetic diphenol with powerful estrogenic properties, causes structural anomalies of the reproductive tract and increases the risk of cancer and genital malformations in children and grandchildren of mothers treated during pregnancy. Conversely, data on DES effects on neurodevelopment and psychiatric disorders in in-utero exposed children and their descendants are rare, especially concerning Autism Spectrum Disorders (ASD). Recent studies presented in this review strengthen the hypothesis that in-utero exposure to DES and also other synthetic estrogens and progestogens, which all are endocrine disruptors, contributes to the pathogenesis of psychiatric disorders, especially ASD. A large epidemiological study in the USA in 2010 reported severe depression in in-utero exposed children (n=1,612), and a French cohort study (n=1,002 in-utero DES exposed children) in 2016 found mainly bipolar disorders, schizophrenia, major depression, suicide attempts, and suicide. Few publications described ASD in in-utero exposed children, mainly a Danish cohort study and a large Chinese epidemiological study. Molecular studies on endocrine disruptors demonstrated the transgenerational induction of diseases and DES epigenetic impact (DNA methylation changes) at two genes implicated in neurodevelopment (ZFP57 and ADAM TS9). We recently described in an informative family, somatic and psychiatric disorders in four generations, particularly ASD in boys of the third and fourth generation. These data show that the principle of precaution must be retained for the protection of future generations: women (pregnant or not) should be extremely vigilant about synthetic hormones.https://www.frontiersin.org/articles/10.3389/fendo.2022.1034959/fulldiethylstilbestrolpsychiatric disordersautismepigeneticsendocrine disruptors |
| spellingShingle | Marie-Odile Soyer-Gobillard Marie-Odile Soyer-Gobillard Laura Gaspari Laura Gaspari Laura Gaspari Philippe Courtet Philippe Courtet Charles Sultan Diethylstilbestrol and autism Frontiers in Endocrinology diethylstilbestrol psychiatric disorders autism epigenetics endocrine disruptors |
| title | Diethylstilbestrol and autism |
| title_full | Diethylstilbestrol and autism |
| title_fullStr | Diethylstilbestrol and autism |
| title_full_unstemmed | Diethylstilbestrol and autism |
| title_short | Diethylstilbestrol and autism |
| title_sort | diethylstilbestrol and autism |
| topic | diethylstilbestrol psychiatric disorders autism epigenetics endocrine disruptors |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1034959/full |
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