The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

<p>Abstract</p> <p>Background</p> <p>The Q151M multi-drug resistance (MDR) pathway in HIV-1 reverse transcriptase (RT) confers reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF). This pathway emerges after long te...

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Bibliographic Details
Main Authors: Gibb Diana M, Parry Chris M, Chintu Chifumbe, Kalumbi Moxmalama, Mulenga Veronica, Kabamba Desire, Gupta Ravi K, Mbisa Jean L, Walker Sarah A, Cane Patricia A, Pillay Deenan
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/8/1/31

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