T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way
Summary: Innate lymphoid cells (ILCs) have been shown to be significantly affected in the small intestine lamina propria and secondary lymphoid organs (SLOs) of conventional lymphopenic mice. How ILCs are regulated by adaptive immunity in SLOs remains unclear. In T cell-deficient mice, ILC2s are sig...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221001267 |
| _version_ | 1818651595734253568 |
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| author | Priscillia Bresler Emmanuel Tejerina Jean Marie Jacob Agnès Legrand Véronique Quellec Sophie Ezine Lucie Peduto Marie Cherrier |
| author_facet | Priscillia Bresler Emmanuel Tejerina Jean Marie Jacob Agnès Legrand Véronique Quellec Sophie Ezine Lucie Peduto Marie Cherrier |
| author_sort | Priscillia Bresler |
| collection | DOAJ |
| description | Summary: Innate lymphoid cells (ILCs) have been shown to be significantly affected in the small intestine lamina propria and secondary lymphoid organs (SLOs) of conventional lymphopenic mice. How ILCs are regulated by adaptive immunity in SLOs remains unclear. In T cell-deficient mice, ILC2s are significantly increased in the mesenteric lymph nodes (MLNs) at the expense of CCR6+ ILC3s, which are nonetheless increased in the peripheral lymph nodes (PLNs). Here, we show that T cells regulate lymph node-resident ILCs in a tissue- and subset-specific way. First, reducing microbial colonization from birth restored CCR6+ ILC3s in the MLNs of T cell-deficient mice. In contrast, T cell reconstitution resulted in the contraction of both MLNs ILC2s and PLNs ILC3s, whereas antagonizing microbial colonization from birth had no impact on these populations. Finally, the accumulation of MLNs ILC2s was partly regulated by T cells through stroma-derived IL-33. |
| first_indexed | 2024-12-17T02:08:37Z |
| format | Article |
| id | doaj.art-55eac2e42e5c4aa58c3f3542ec1e1e0e |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T02:08:37Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-55eac2e42e5c4aa58c3f3542ec1e1e0e2022-12-21T22:07:37ZengElsevieriScience2589-00422021-03-01243102158T cells regulate lymph node-resident ILC populations in a tissue and subset-specific wayPriscillia Bresler0Emmanuel Tejerina1Jean Marie Jacob2Agnès Legrand3Véronique Quellec4Sophie Ezine5Lucie Peduto6Marie Cherrier7Institut Necker Enfants Malades, Université Paris Descartes, INSERM U1151, CNRS UMR 8253, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, FranceInstitut Necker Enfants Malades, Université Paris Descartes, INSERM U1151, CNRS UMR 8253, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, FranceStroma, Inflammation & Tissue Repair Unit, Institut Pasteur, Inserm U1224, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, FranceInstitut Necker Enfants Malades, Université Paris Descartes, INSERM U1151, CNRS UMR 8253, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, FranceInstitut Necker Enfants Malades, Université Paris Descartes, INSERM U1151, CNRS UMR 8253, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, FranceInstitut Necker Enfants Malades, Université Paris Descartes, INSERM U1151, CNRS UMR 8253, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, FranceStroma, Inflammation & Tissue Repair Unit, Institut Pasteur, Inserm U1224, Paris, FranceInstitut Imagine, Université Paris Descartes, INSERM U1163, Laboratory of Intestinal Immunity, 24 Boulevard du Montparnasse, 75015 Paris, France; Corresponding authorSummary: Innate lymphoid cells (ILCs) have been shown to be significantly affected in the small intestine lamina propria and secondary lymphoid organs (SLOs) of conventional lymphopenic mice. How ILCs are regulated by adaptive immunity in SLOs remains unclear. In T cell-deficient mice, ILC2s are significantly increased in the mesenteric lymph nodes (MLNs) at the expense of CCR6+ ILC3s, which are nonetheless increased in the peripheral lymph nodes (PLNs). Here, we show that T cells regulate lymph node-resident ILCs in a tissue- and subset-specific way. First, reducing microbial colonization from birth restored CCR6+ ILC3s in the MLNs of T cell-deficient mice. In contrast, T cell reconstitution resulted in the contraction of both MLNs ILC2s and PLNs ILC3s, whereas antagonizing microbial colonization from birth had no impact on these populations. Finally, the accumulation of MLNs ILC2s was partly regulated by T cells through stroma-derived IL-33.http://www.sciencedirect.com/science/article/pii/S2589004221001267ImmunologyComponents of the Immune SystemMicrobiome |
| spellingShingle | Priscillia Bresler Emmanuel Tejerina Jean Marie Jacob Agnès Legrand Véronique Quellec Sophie Ezine Lucie Peduto Marie Cherrier T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way iScience Immunology Components of the Immune System Microbiome |
| title | T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way |
| title_full | T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way |
| title_fullStr | T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way |
| title_full_unstemmed | T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way |
| title_short | T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way |
| title_sort | t cells regulate lymph node resident ilc populations in a tissue and subset specific way |
| topic | Immunology Components of the Immune System Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221001267 |
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