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author Narda Medina
Juan Carlos Soto-Debrán
Danila Seidel
Isin Akyar
Hamid Badali
Aleksandra Barac
Stéphane Bretagne
Yasemin Cag
Carole Cassagne
Carmen Castro
Arunaloke Chakrabarti
Eric Dannaoui
Celia Cardozo
Julio Garcia-Rodriguez
Juliette Guitard
Petr Hamal
Martin Hoenigl
Tomasz Jagielski
Sadegh Khodavaisy
Giuliana Lo Cascio
María Carmen Martínez-Rubio
Joseph Meletiadis
Patricia Muñoz
Elżbieta Ochman
Teresa Peláez
Ana Perez-Ayala Balzola
Juergen Prattes
Emmanuel Roilides
Maite Ruíz-Pérez de Pipaón
Raphael Stauf
Jörg Steinmann
Ana Isabel Suárez-Barrenechea
Rocío Tejero
Laura Trovato
Lourdes Viñuela
Thanwa Wongsuk
Iwona Żak
Hossein Zarrinfar
Cornelia Lass-Flörl
Sevtap Arikan-Akdagli
Ana Alastruey-Izquierdo
on behalf of MixInYeast Study Group from EFISG
author_facet Narda Medina
Juan Carlos Soto-Debrán
Danila Seidel
Isin Akyar
Hamid Badali
Aleksandra Barac
Stéphane Bretagne
Yasemin Cag
Carole Cassagne
Carmen Castro
Arunaloke Chakrabarti
Eric Dannaoui
Celia Cardozo
Julio Garcia-Rodriguez
Juliette Guitard
Petr Hamal
Martin Hoenigl
Tomasz Jagielski
Sadegh Khodavaisy
Giuliana Lo Cascio
María Carmen Martínez-Rubio
Joseph Meletiadis
Patricia Muñoz
Elżbieta Ochman
Teresa Peláez
Ana Perez-Ayala Balzola
Juergen Prattes
Emmanuel Roilides
Maite Ruíz-Pérez de Pipaón
Raphael Stauf
Jörg Steinmann
Ana Isabel Suárez-Barrenechea
Rocío Tejero
Laura Trovato
Lourdes Viñuela
Thanwa Wongsuk
Iwona Żak
Hossein Zarrinfar
Cornelia Lass-Flörl
Sevtap Arikan-Akdagli
Ana Alastruey-Izquierdo
on behalf of MixInYeast Study Group from EFISG
author_sort Narda Medina
collection DOAJ
description Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were <i>Candida albicans/C. glabrata</i> (42, 34.4%), <i>C. albicans/C. parapsilosis</i> (17, 14%), and <i>C. glabrata/C. tropicalis</i> (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions.
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spelling doaj.art-55eb44aac680476f9b349b2cbac6b0082023-11-21T02:57:25ZengMDPI AGJournal of Fungi2309-608X2020-12-01711310.3390/jof7010013MixInYeast: A Multicenter Study on Mixed Yeast InfectionsNarda Medina0Juan Carlos Soto-Debrán1Danila Seidel2Isin Akyar3Hamid Badali4Aleksandra Barac5Stéphane Bretagne6Yasemin Cag7Carole Cassagne8Carmen Castro9Arunaloke Chakrabarti10Eric Dannaoui11Celia Cardozo12Julio Garcia-Rodriguez13Juliette Guitard14Petr Hamal15Martin Hoenigl16Tomasz Jagielski17Sadegh Khodavaisy18Giuliana Lo Cascio19María Carmen Martínez-Rubio20Joseph Meletiadis21Patricia Muñoz22Elżbieta Ochman23Teresa Peláez24Ana Perez-Ayala Balzola25Juergen Prattes26Emmanuel Roilides27Maite Ruíz-Pérez de Pipaón28Raphael Stauf29Jörg Steinmann30Ana Isabel Suárez-Barrenechea31Rocío Tejero32Laura Trovato33Lourdes Viñuela34Thanwa Wongsuk35Iwona Żak36Hossein Zarrinfar37Cornelia Lass-Flörl38Sevtap Arikan-Akdagli39Ana Alastruey-Izquierdo40on behalf of MixInYeast Study Group from EFISGMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, SpainMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, SpainCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Medical Microbiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, 34758 Istanbul, TurkeyInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari 48157-33971, IranClinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaLaboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), 75010 Paris, FranceIstanbul Medeniyet University Goztepe Training and Research Hospital, 34722 Istanbul, TurkeyAix-Marseille University, UMR MD3 IP-TPT, 13885 Marseilles, FranceMicrobiology Service, Clinical Unit of Infectious Diseases and Microbiology, Hospital Universitario Valme, 41014 Sevilla, SpainDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaUnité de Parasitologie-Mycologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP) Université de Paris, 75015 Paris, FranceHospital Universitario Clínic, 08036 Barcelona, SpainHospital Universitario La Paz, 28046 Madrid, SpainService de Parasitologie-Mycologie, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Inserm, 75012 Paris, FranceDepartment of Microbiology, Palacky University, Faculty of Medicine and Dentistry and University Hospital, 775 15 Olomouc, Czech RepublicDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA 92093, USADepartment of Medical Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, I. Miecznikowa 1, 02-096 Warsaw, PolandDivision of Molecular Biology & Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran 14167-53955, IranMicrobiology and Virology Unit, Department of Pathology and Diagnostic, Azienda Ospedaliera Universitaria Integrata, 30126 Verona, ItalyHospital Universitario de Puerto Real, 11510 Cádiz, SpainClinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Haidari, 12462 Athens, GreeceClinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañon, 28007 Madrid, SpainDepartment of Clinical Microbiology, The Maria Skłodowska-Curie Institute of Oncology, W. K. Roentgena 5, 02-781 Warsaw, PolandHospital Universitario Central de Asturias (HUCA), Fundación para la Investigación Biomédica y la Innovación Biosanitaria del Principado de Asturias (FINBA), 33011 Asturias, SpainMicrobiology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainSection of Infectious Diseases and Tropical Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, AustriaInfectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration General Hospital, 54642 Thessaloniki, GreeceDepartment of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen del Rocío, 41013 Seville, SpainInstitute of Clinical Hygiene, Medical Microbiology and Infectiology, Klinikum Nürnberg, Paracelsus Medical University, 90419 Nuremberg, GermanyInstitute of Clinical Hygiene, Medical Microbiology and Infectiology, Klinikum Nürnberg, Paracelsus Medical University, 90419 Nuremberg, GermanyInfectious disease and Clinical Microbiology Department, Virgen Macarena University Hospital, 41009 Sevilla, SpainUnit of Microbiology, Hospital Universitario Reina Sofía, 14004 Cordoba, SpainU.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-Vittorio Emanuele”, 95123 Catania, ItalyServicio de Microbiología Hospital Universitario Río Hortega, 47012 Valladolid, SpainDepartment of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, ThailandDepartment of Clinical Microbiology, Children’s University Hospital of Cracow, 30-663 Kraków, PolandAllergy Research Center, Mashhad University of Medical Sciences, Mashhad 91766-99199, IranDepartment of Hygiene und Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Medical Microbiology, Hacettepe University Medical School, 06100 Ankara, TurkeyMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, SpainInvasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were <i>Candida albicans/C. glabrata</i> (42, 34.4%), <i>C. albicans/C. parapsilosis</i> (17, 14%), and <i>C. glabrata/C. tropicalis</i> (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions.https://www.mdpi.com/2309-608X/7/1/13yeastchrome agarinvasive candidiasis<i>Candida</i>mix infectionspolymicrobial infections
spellingShingle Narda Medina
Juan Carlos Soto-Debrán
Danila Seidel
Isin Akyar
Hamid Badali
Aleksandra Barac
Stéphane Bretagne
Yasemin Cag
Carole Cassagne
Carmen Castro
Arunaloke Chakrabarti
Eric Dannaoui
Celia Cardozo
Julio Garcia-Rodriguez
Juliette Guitard
Petr Hamal
Martin Hoenigl
Tomasz Jagielski
Sadegh Khodavaisy
Giuliana Lo Cascio
María Carmen Martínez-Rubio
Joseph Meletiadis
Patricia Muñoz
Elżbieta Ochman
Teresa Peláez
Ana Perez-Ayala Balzola
Juergen Prattes
Emmanuel Roilides
Maite Ruíz-Pérez de Pipaón
Raphael Stauf
Jörg Steinmann
Ana Isabel Suárez-Barrenechea
Rocío Tejero
Laura Trovato
Lourdes Viñuela
Thanwa Wongsuk
Iwona Żak
Hossein Zarrinfar
Cornelia Lass-Flörl
Sevtap Arikan-Akdagli
Ana Alastruey-Izquierdo
on behalf of MixInYeast Study Group from EFISG
MixInYeast: A Multicenter Study on Mixed Yeast Infections
Journal of Fungi
yeast
chrome agar
invasive candidiasis
<i>Candida</i>
mix infections
polymicrobial infections
title MixInYeast: A Multicenter Study on Mixed Yeast Infections
title_full MixInYeast: A Multicenter Study on Mixed Yeast Infections
title_fullStr MixInYeast: A Multicenter Study on Mixed Yeast Infections
title_full_unstemmed MixInYeast: A Multicenter Study on Mixed Yeast Infections
title_short MixInYeast: A Multicenter Study on Mixed Yeast Infections
title_sort mixinyeast a multicenter study on mixed yeast infections
topic yeast
chrome agar
invasive candidiasis
<i>Candida</i>
mix infections
polymicrobial infections
url https://www.mdpi.com/2309-608X/7/1/13
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