MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma

Improving cellular access to energy substrates is one strategy to overcome observed declines in energy production and utilization in the aged and pathologic central nervous system. Monocarboxylate transporters (MCTs), the movers of lactate, pyruvate, and ketone bodies into or out of a cell, are sign...

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Bibliographic Details
Main Authors: Mohammad Harun-Or-Rashid, Nathaniel Pappenhagen, Ryan Zubricky, Lucy Coughlin, Assraa Hassan Jassim, Denise M. Inman
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Monocarboxylate transporter
Glaucoma
Retinal ganglion cell
Ocular hypertension
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302199

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