An on-demand bioresorbable neurostimulator
Abstract Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable ener...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-42791-5 |
| _version_ | 1797630098974703616 |
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| author | Dong-Min Lee Minki Kang Inah Hyun Byung-Joon Park Hye Jin Kim Soo Hyun Nam Hong-Joon Yoon Hanjun Ryu Hyun-moon Park Byung-Ok Choi Sang-Woo Kim |
| author_facet | Dong-Min Lee Minki Kang Inah Hyun Byung-Joon Park Hye Jin Kim Soo Hyun Nam Hong-Joon Yoon Hanjun Ryu Hyun-moon Park Byung-Ok Choi Sang-Woo Kim |
| author_sort | Dong-Min Lee |
| collection | DOAJ |
| description | Abstract Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy. |
| first_indexed | 2024-03-11T11:03:11Z |
| format | Article |
| id | doaj.art-55ee47c12b4c491984f20817a29279fb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-11T11:03:11Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-55ee47c12b4c491984f20817a29279fb2023-11-12T12:21:54ZengNature PortfolioNature Communications2041-17232023-11-0114111110.1038/s41467-023-42791-5An on-demand bioresorbable neurostimulatorDong-Min Lee0Minki Kang1Inah Hyun2Byung-Joon Park3Hye Jin Kim4Soo Hyun Nam5Hong-Joon Yoon6Hanjun Ryu7Hyun-moon Park8Byung-Ok Choi9Sang-Woo Kim10Department of Materials Science and Engineering, Yonsei UniversitySchool of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU)Department of Materials Science and Engineering, Yonsei UniversityDepartment of Materials Science and Engineering, Yonsei UniversityDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineCell and Gene Therapy Institute (CGTI), Samsung Medical CenterDepartment of Electronic Engineering, Gachon UniversityDepartment of Advanced Materials Engineering, Chung-Ang UniversityResearch and Development Center, Energy-Mining Co., LTD.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Materials Science and Engineering, Yonsei UniversityAbstract Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.https://doi.org/10.1038/s41467-023-42791-5 |
| spellingShingle | Dong-Min Lee Minki Kang Inah Hyun Byung-Joon Park Hye Jin Kim Soo Hyun Nam Hong-Joon Yoon Hanjun Ryu Hyun-moon Park Byung-Ok Choi Sang-Woo Kim An on-demand bioresorbable neurostimulator Nature Communications |
| title | An on-demand bioresorbable neurostimulator |
| title_full | An on-demand bioresorbable neurostimulator |
| title_fullStr | An on-demand bioresorbable neurostimulator |
| title_full_unstemmed | An on-demand bioresorbable neurostimulator |
| title_short | An on-demand bioresorbable neurostimulator |
| title_sort | on demand bioresorbable neurostimulator |
| url | https://doi.org/10.1038/s41467-023-42791-5 |
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