Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population
Abstract Objectives To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population. Methods The Hardy-Weinberg equilibrium (HWE) and the rela...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Genes and Environment |
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| Online Access: | https://doi.org/10.1186/s41021-021-00194-2 |
| _version_ | 1818456604246278144 |
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| author | Peng Xue Haihong Cao Zhimin Ma Ying Zhou Nian Wang |
| author_facet | Peng Xue Haihong Cao Zhimin Ma Ying Zhou Nian Wang |
| author_sort | Peng Xue |
| collection | DOAJ |
| description | Abstract Objectives To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population. Methods The Hardy-Weinberg equilibrium (HWE) and the relationship between TCF7L2 gene single nucleotide polymorphism (SNPs) and DN susceptibility were evaluated by SNPStats. The interaction among four SNPs and environmental factors were tested by generalized multifactor dimensionality reduction (GMDR). The consistency of cross validation, accuracy of test balance and sign test were calculated to evaluate the interaction of each selection. The logistic regression was used to test the interaction between rs7903146 and current smoking by stratified analysis. Results Logistic regression analysis indicated that the DN risk of rs7903146-T allele carriers were obviously higher than that in CC genotype carriers (CT + TT versus CC), adjusted OR (95 %CI) = 1.64 (1.24–2.06). However, we also discovered that people with rs12255372, rs11196205 and rs290487 minor allele had non-significant difference risk of DN compared with people with major allele. The GMDR model found a significant two-locus model (p = 0.0100) including rs7903146 and current smoking, suggesting a potential gene–environment interaction between rs7903146 and current smoking. Compared with never smokers with rs7903146- CC genotype, current smokers with rs7903146- CT or TT genotype had the highest DN risk. After covariate adjustment, OR (95 %CI) was 2.15 (1.58–2.78). Conclusions We found a significant relationship of rs7903146-T alleles, and the interaction between rs7903146-T and current smoking with increased DN risk. |
| first_indexed | 2024-12-14T22:29:18Z |
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| id | doaj.art-55ee9f8445794458ba6867c1b64f5ad9 |
| institution | Directory Open Access Journal |
| issn | 1880-7062 |
| language | English |
| last_indexed | 2024-12-14T22:29:18Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Genes and Environment |
| spelling | doaj.art-55ee9f8445794458ba6867c1b64f5ad92022-12-21T22:45:17ZengBMCGenes and Environment1880-70622021-06-014311610.1186/s41021-021-00194-2Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han populationPeng Xue0Haihong Cao1Zhimin Ma2Ying Zhou3Nian Wang4Department of endocrinology, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversityDepartment of endocrinology, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversityDepartment of endocrinology, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversityDepartment of endocrinology, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversityDepartment of endocrinology, the Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversityAbstract Objectives To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population. Methods The Hardy-Weinberg equilibrium (HWE) and the relationship between TCF7L2 gene single nucleotide polymorphism (SNPs) and DN susceptibility were evaluated by SNPStats. The interaction among four SNPs and environmental factors were tested by generalized multifactor dimensionality reduction (GMDR). The consistency of cross validation, accuracy of test balance and sign test were calculated to evaluate the interaction of each selection. The logistic regression was used to test the interaction between rs7903146 and current smoking by stratified analysis. Results Logistic regression analysis indicated that the DN risk of rs7903146-T allele carriers were obviously higher than that in CC genotype carriers (CT + TT versus CC), adjusted OR (95 %CI) = 1.64 (1.24–2.06). However, we also discovered that people with rs12255372, rs11196205 and rs290487 minor allele had non-significant difference risk of DN compared with people with major allele. The GMDR model found a significant two-locus model (p = 0.0100) including rs7903146 and current smoking, suggesting a potential gene–environment interaction between rs7903146 and current smoking. Compared with never smokers with rs7903146- CC genotype, current smokers with rs7903146- CT or TT genotype had the highest DN risk. After covariate adjustment, OR (95 %CI) was 2.15 (1.58–2.78). Conclusions We found a significant relationship of rs7903146-T alleles, and the interaction between rs7903146-T and current smoking with increased DN risk.https://doi.org/10.1186/s41021-021-00194-2InteractionTranscription factor 7-like 2PolymorphismsDiabetic nephropathyTranscription factor 7-like 2 |
| spellingShingle | Peng Xue Haihong Cao Zhimin Ma Ying Zhou Nian Wang Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population Genes and Environment Interaction Transcription factor 7-like 2 Polymorphisms Diabetic nephropathy Transcription factor 7-like 2 |
| title | Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population |
| title_full | Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population |
| title_fullStr | Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population |
| title_full_unstemmed | Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population |
| title_short | Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population |
| title_sort | transcription factor 7 like 2 gene smoking interaction on the risk of diabetic nephropathy in chinese han population |
| topic | Interaction Transcription factor 7-like 2 Polymorphisms Diabetic nephropathy Transcription factor 7-like 2 |
| url | https://doi.org/10.1186/s41021-021-00194-2 |
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