Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy.
BACKGROUND:A decline in estimated glomerular filtration rate (eGFR) is reportedly associated with increased prevalence rates of cognitive impairment. However, data concerning the association between the cerebral saturation of oxygen (rSO2) and cognitive function of patients with chronic kidney disea...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6016918?pdf=render |
| _version_ | 1818246354417221632 |
|---|---|
| author | Haruhisa Miyazawa Susumu Ookawara Kiyonori Ito Yuichiro Ueda Katsunori Yanai Hiroki Ishii Yuko Mutsuyoshi Taisuke Kitano Mitsutoshi Shindo Akinori Aomatsu Keiji Hirai Taro Hoshino Yoshiyuki Morishita |
| author_facet | Haruhisa Miyazawa Susumu Ookawara Kiyonori Ito Yuichiro Ueda Katsunori Yanai Hiroki Ishii Yuko Mutsuyoshi Taisuke Kitano Mitsutoshi Shindo Akinori Aomatsu Keiji Hirai Taro Hoshino Yoshiyuki Morishita |
| author_sort | Haruhisa Miyazawa |
| collection | DOAJ |
| description | BACKGROUND:A decline in estimated glomerular filtration rate (eGFR) is reportedly associated with increased prevalence rates of cognitive impairment. However, data concerning the association between the cerebral saturation of oxygen (rSO2) and cognitive function of patients with chronic kidney disease (CKD) is limited. This study aimed to (i) elucidate the clinical factors associating with cerebral rSO2 and (ii) investigate the association between cerebral rSO2 and cognitive assessment in CKD patients. METHODS:A total of 40 CKD patients not requiring dialysis (26 men and 14 women; mean age, 61.0 ± 2.7 years) were recruited. The numbers of patients at each CKD stage were as follows: G1, 5; G2, 8; G3a, 6; G3b, 5; G4, 11; and G5, 5. Cerebral rSO2 was monitored at the forehead using the oxygen saturation monitor INVOS 5100C. The cognitive function of each patient was confirmed using the Mini-Mental State Examination (MMSE). RESULTS:Cerebral rSO2 levels were significantly higher in CKD patients than in hemodialysis patients (63.8 ± 1.5% vs. 44.9 ± 2.2%, p < 0.001). Multiple regression analysis showed that cerebral rSO2 was independently associated with eGFR (standardized coefficient: 0.530), serum albumin concentration (standardized coefficient: 0.365), and serum sodium concentration (standardized coefficient: 0.224). Furthermore, MMSE showed a significantly positive correlation with cerebral rSO2 (r = 0.624, p < 0.001). CONCLUSIONS:Cerebral rSO2 was affected by eGFR and serum albumin and sodium concentrations in CKD patients. Furthermore, cerebral rSO2 monitoring, which reflected MMSE scores, might be a useful method for assessing cognitive function in CKD patients. |
| first_indexed | 2024-12-12T14:47:29Z |
| format | Article |
| id | doaj.art-55eeedce7077438e85289090da18e862 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T14:47:29Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-55eeedce7077438e85289090da18e8622022-12-22T00:21:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019936610.1371/journal.pone.0199366Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy.Haruhisa MiyazawaSusumu OokawaraKiyonori ItoYuichiro UedaKatsunori YanaiHiroki IshiiYuko MutsuyoshiTaisuke KitanoMitsutoshi ShindoAkinori AomatsuKeiji HiraiTaro HoshinoYoshiyuki MorishitaBACKGROUND:A decline in estimated glomerular filtration rate (eGFR) is reportedly associated with increased prevalence rates of cognitive impairment. However, data concerning the association between the cerebral saturation of oxygen (rSO2) and cognitive function of patients with chronic kidney disease (CKD) is limited. This study aimed to (i) elucidate the clinical factors associating with cerebral rSO2 and (ii) investigate the association between cerebral rSO2 and cognitive assessment in CKD patients. METHODS:A total of 40 CKD patients not requiring dialysis (26 men and 14 women; mean age, 61.0 ± 2.7 years) were recruited. The numbers of patients at each CKD stage were as follows: G1, 5; G2, 8; G3a, 6; G3b, 5; G4, 11; and G5, 5. Cerebral rSO2 was monitored at the forehead using the oxygen saturation monitor INVOS 5100C. The cognitive function of each patient was confirmed using the Mini-Mental State Examination (MMSE). RESULTS:Cerebral rSO2 levels were significantly higher in CKD patients than in hemodialysis patients (63.8 ± 1.5% vs. 44.9 ± 2.2%, p < 0.001). Multiple regression analysis showed that cerebral rSO2 was independently associated with eGFR (standardized coefficient: 0.530), serum albumin concentration (standardized coefficient: 0.365), and serum sodium concentration (standardized coefficient: 0.224). Furthermore, MMSE showed a significantly positive correlation with cerebral rSO2 (r = 0.624, p < 0.001). CONCLUSIONS:Cerebral rSO2 was affected by eGFR and serum albumin and sodium concentrations in CKD patients. Furthermore, cerebral rSO2 monitoring, which reflected MMSE scores, might be a useful method for assessing cognitive function in CKD patients.http://europepmc.org/articles/PMC6016918?pdf=render |
| spellingShingle | Haruhisa Miyazawa Susumu Ookawara Kiyonori Ito Yuichiro Ueda Katsunori Yanai Hiroki Ishii Yuko Mutsuyoshi Taisuke Kitano Mitsutoshi Shindo Akinori Aomatsu Keiji Hirai Taro Hoshino Yoshiyuki Morishita Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. PLoS ONE |
| title | Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. |
| title_full | Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. |
| title_fullStr | Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. |
| title_full_unstemmed | Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. |
| title_short | Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy. |
| title_sort | association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy |
| url | http://europepmc.org/articles/PMC6016918?pdf=render |
| work_keys_str_mv | AT haruhisamiyazawa associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT susumuookawara associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT kiyonoriito associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT yuichiroueda associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT katsunoriyanai associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT hirokiishii associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT yukomutsuyoshi associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT taisukekitano associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT mitsutoshishindo associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT akinoriaomatsu associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT keijihirai associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT tarohoshino associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy AT yoshiyukimorishita associationofcerebraloxygenationwithestimatedglomerularfiltrationrateandcognitivefunctioninchronickidneydiseasepatientswithoutdialysistherapy |