Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although <i>Erythronium japonicum</i> exhibits various health benefits, the role of <...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| author | Dong Wook Lim Joon Park Daeseok Han Jaekwang Lee Yun Tai Kim Changho Lee |
| author_facet | Dong Wook Lim Joon Park Daeseok Han Jaekwang Lee Yun Tai Kim Changho Lee |
| author_sort | Dong Wook Lim |
| collection | DOAJ |
| description | Neuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although <i>Erythronium japonicum</i> exhibits various health benefits, the role of <i>E. japonicum</i> extract (EJE) in inflammation-associated depression is unknown. This study aimed to explore the anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using the open field test (OFT), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST). LPS-treated mice had significantly increased immobility time in the TST and FST, decreased step-through latency time in the PAT, and decreased locomotor activity in the OFT. However, administration of 100 and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE also prevented the increase in mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and the decrease in IL-10 levels by inhibiting nuclear factor-κB (NF-κB) subunit p65 phosphorylation. Additionally, LPS-treated mice showed markedly decreased brain-derived neurotrophic factor (BDNF) levels and phosphorylation of phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly increased these levels in the hippocampus. These results suggest that EJE ameliorated LPS-induced depressive-like behavior by reducing LPS-induced neuroinflammation and activating the BDNF-PI3K/Akt pathway. |
| first_indexed | 2024-03-10T14:07:43Z |
| format | Article |
| id | doaj.art-55f14721d5484fb2ab16ae1527167718 |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:07:43Z |
| publishDate | 2020-12-01 |
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| series | Nutrients |
| spelling | doaj.art-55f14721d5484fb2ab16ae15271677182023-11-21T00:29:29ZengMDPI AGNutrients2072-66432020-12-011212380910.3390/nu12123809Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in MiceDong Wook Lim0Joon Park1Daeseok Han2Jaekwang Lee3Yun Tai Kim4Changho Lee5Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, KoreaNeuroinflammation is associated with an increased risk of depression. Lipopolysaccharide (LPS) treatment is known to induce pro-inflammatory cytokine secretion and a depressive-like phenotype in mice. Although <i>Erythronium japonicum</i> exhibits various health benefits, the role of <i>E. japonicum</i> extract (EJE) in inflammation-associated depression is unknown. This study aimed to explore the anti-inflammatory effect of EJE on LPS-induced depressive symptoms in mice using the open field test (OFT), passive avoidance test (PAT), tail suspension test (TST), and forced swim test (FST). LPS-treated mice had significantly increased immobility time in the TST and FST, decreased step-through latency time in the PAT, and decreased locomotor activity in the OFT. However, administration of 100 and 300 mg/kg of EJE significantly improved these depressive-like behaviors. EJE also prevented the increase in mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1), and the decrease in IL-10 levels by inhibiting nuclear factor-κB (NF-κB) subunit p65 phosphorylation. Additionally, LPS-treated mice showed markedly decreased brain-derived neurotrophic factor (BDNF) levels and phosphorylation of phosphoinositide 3-kinase (PI3K) and Akt, while EJE treatment significantly increased these levels in the hippocampus. These results suggest that EJE ameliorated LPS-induced depressive-like behavior by reducing LPS-induced neuroinflammation and activating the BDNF-PI3K/Akt pathway.https://www.mdpi.com/2072-6643/12/12/3809<i>Erythronium japonicum</i>lipopolysaccharideanti-inflammationdepression |
| spellingShingle | Dong Wook Lim Joon Park Daeseok Han Jaekwang Lee Yun Tai Kim Changho Lee Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice Nutrients <i>Erythronium japonicum</i> lipopolysaccharide anti-inflammation depression |
| title | Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
| title_full | Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
| title_fullStr | Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
| title_full_unstemmed | Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
| title_short | Anti-Inflammatory Effects of Asian Fawn Lily (<i>Erythronium japonicum</i>) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice |
| title_sort | anti inflammatory effects of asian fawn lily i erythronium japonicum i extract on lipopolysaccharide induced depressive like behavior in mice |
| topic | <i>Erythronium japonicum</i> lipopolysaccharide anti-inflammation depression |
| url | https://www.mdpi.com/2072-6643/12/12/3809 |
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