HIF-1α Directly Controls WNT7A Expression During Myogenesis

HIF-1α Directly Controls WNT7A Expression During Myogenesis

Herein we unveil that Hypoxia-inducible factor-1α (HIF-1α) directly regulates WNT7A expression during myogenesis. In fact, chromatin immunoprecipitation (ChiP) and site-directed mutagenesis experiments revealed two distinct hypoxia response elements (HREs) that are specific HIF-1α binding sites on t...

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Bibliographic Details
Main Authors: Federica Cirillo, Giulia Resmini, Elia Angelino, Michele Ferrara, Adriana Tarantino, Marco Piccoli, Paola Rota, Andrea Ghiroldi, Michelle M. Monasky, Giuseppe Ciconte, Carlo Pappone, Andrea Graziani, Luigi Anastasia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hypoxia-inducible factor-1α
WNT7a
myogenesis
hypertrophy
Prolyl-hydroxylases
FG-4592
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.593508/full

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