JunB: a paradigm for Jun family in immune response and cancer
Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeos...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1222265/full |
| _version_ | 1797693753082773504 |
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| author | Fu-jia Ren Xiao-yu Cai Yao Yao Guo-ying Fang |
| author_facet | Fu-jia Ren Xiao-yu Cai Yao Yao Guo-ying Fang |
| author_sort | Fu-jia Ren |
| collection | DOAJ |
| description | Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes. |
| first_indexed | 2024-03-12T02:48:05Z |
| format | Article |
| id | doaj.art-55f4804782f74be484d5fe3080386895 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-12T02:48:05Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-55f4804782f74be484d5fe30803868952023-09-04T06:35:07ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-09-011310.3389/fcimb.2023.12222651222265JunB: a paradigm for Jun family in immune response and cancerFu-jia Ren0Xiao-yu Cai1Yao Yao2Guo-ying Fang3Department of Pharmacy, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, ChinaDepartment of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pharmacy, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Pharmacy, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, ChinaJun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1222265/fullAP-1JunBimmune responsetumorigenesistumor microenvironment |
| spellingShingle | Fu-jia Ren Xiao-yu Cai Yao Yao Guo-ying Fang JunB: a paradigm for Jun family in immune response and cancer Frontiers in Cellular and Infection Microbiology AP-1 JunB immune response tumorigenesis tumor microenvironment |
| title | JunB: a paradigm for Jun family in immune response and cancer |
| title_full | JunB: a paradigm for Jun family in immune response and cancer |
| title_fullStr | JunB: a paradigm for Jun family in immune response and cancer |
| title_full_unstemmed | JunB: a paradigm for Jun family in immune response and cancer |
| title_short | JunB: a paradigm for Jun family in immune response and cancer |
| title_sort | junb a paradigm for jun family in immune response and cancer |
| topic | AP-1 JunB immune response tumorigenesis tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1222265/full |
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