Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota
Background and aim: Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing eviden...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411022000013 |
| _version_ | 1797870516441186304 |
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| author | Pei-Sheng Lee Ying-Ying Lu Kalyanam Nagabhushanam Chi-Tang Ho Hui-Ching Mei Min-Hsiung Pan |
| author_facet | Pei-Sheng Lee Ying-Ying Lu Kalyanam Nagabhushanam Chi-Tang Ho Hui-Ching Mei Min-Hsiung Pan |
| author_sort | Pei-Sheng Lee |
| collection | DOAJ |
| description | Background and aim: Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing evidence has identified the gut microbiota as a potential factor in the pathophysiology of obesity. Calebin A is a non-curcuminoid novel compound derived from the rhizome of medicinal turmeric with putative anti-obesity effects. However, its ability on promoting thermogenesis and modulating gut microbiota remain unclear. Experimental procedure: C57BL/6J mice were fed either normal diet or high-fat diet (HFD) supplement with calebin A (0.1 and 0.5%) diet for 12 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Results and conclusion: Mice treated with calebin A shows a remarkable alteration in microbiota composition compared with that of normal diet-fed or HFD-fed mice and is characterized by an enrichment of Akkermansia, Butyricicoccus, Ruminiclostridium_9, and unidentified_Ruminococcaceae. We also explored that calebin A reduce the weight and blood sugar of mice that are induced by HFD, and show a dose-dependent reaction. Moreover, calebin A decreases the weight of white, beige, and brown adipose tissue, and also restores liver weight. In cold exposure experiments, calebin A can better maintain rectal temperature through thermogenesis. In summary, calebin A has a good thermogenesis function and is effective in anti-obesity. It can be used as a novel gut microbiota modulator to prevent HFD-induced obesity. |
| first_indexed | 2024-04-10T00:29:43Z |
| format | Article |
| id | doaj.art-55f57e896d1e410194da1d07ed017f84 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-10T00:29:43Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-55f57e896d1e410194da1d07ed017f842023-03-15T04:28:15ZengElsevierJournal of Traditional and Complementary Medicine2225-41102023-03-01132119127Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiotaPei-Sheng Lee0Ying-Ying Lu1Kalyanam Nagabhushanam2Chi-Tang Ho3Hui-Ching Mei4Min-Hsiung Pan5Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, TaiwanDepartment of Natural Science Education, National Taipei University of Education, Taipei, TaiwanSabinsa Corporation, East Windsor, NJ, 08520, USADepartment of Food Science, Rutgers University, New Brunswick, NJ, 08901, USADepartment of Natural Science Education, National Taipei University of Education, Taipei, Taiwan; Corresponding author.Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; Corresponding author. Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.Background and aim: Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing evidence has identified the gut microbiota as a potential factor in the pathophysiology of obesity. Calebin A is a non-curcuminoid novel compound derived from the rhizome of medicinal turmeric with putative anti-obesity effects. However, its ability on promoting thermogenesis and modulating gut microbiota remain unclear. Experimental procedure: C57BL/6J mice were fed either normal diet or high-fat diet (HFD) supplement with calebin A (0.1 and 0.5%) diet for 12 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Results and conclusion: Mice treated with calebin A shows a remarkable alteration in microbiota composition compared with that of normal diet-fed or HFD-fed mice and is characterized by an enrichment of Akkermansia, Butyricicoccus, Ruminiclostridium_9, and unidentified_Ruminococcaceae. We also explored that calebin A reduce the weight and blood sugar of mice that are induced by HFD, and show a dose-dependent reaction. Moreover, calebin A decreases the weight of white, beige, and brown adipose tissue, and also restores liver weight. In cold exposure experiments, calebin A can better maintain rectal temperature through thermogenesis. In summary, calebin A has a good thermogenesis function and is effective in anti-obesity. It can be used as a novel gut microbiota modulator to prevent HFD-induced obesity.http://www.sciencedirect.com/science/article/pii/S2225411022000013Calebin AObesityGut microbiotaThermogenesisAnti-Obesity |
| spellingShingle | Pei-Sheng Lee Ying-Ying Lu Kalyanam Nagabhushanam Chi-Tang Ho Hui-Ching Mei Min-Hsiung Pan Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota Journal of Traditional and Complementary Medicine Calebin A Obesity Gut microbiota Thermogenesis Anti-Obesity |
| title | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| title_full | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| title_fullStr | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| title_full_unstemmed | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| title_short | Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| title_sort | calebin a prevents hfd induced obesity in mice by promoting thermogenesis and modulating gut microbiota |
| topic | Calebin A Obesity Gut microbiota Thermogenesis Anti-Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2225411022000013 |
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