Micafungin in the treatment of invasive candidiasis and invasive aspergillosis
Nathan P Wiederhold1, Jason M Cota2, Christopher R Frei11University of Texas at Austin College of Pharmacy, Austin, Texas, USA; 2University of the Incarnate Word Feik School of Pharmacy, San Antonio, Texas, USAAbstract: Micafungin is an echinocandin antifungal agent available for clinical use in Jap...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2009-01-01
|
| Series: | Infection and Drug Resistance |
| Online Access: | http://www.dovepress.com/micafungin-in-the-treatment-of-invasive-candidiasis-and-invasive-asper-a2784 |
| _version_ | 1811335118990606336 |
|---|---|
| author | Nathan P Wiederhold Jason M Cota Christopher R Frei |
| author_facet | Nathan P Wiederhold Jason M Cota Christopher R Frei |
| author_sort | Nathan P Wiederhold |
| collection | DOAJ |
| description | Nathan P Wiederhold1, Jason M Cota2, Christopher R Frei11University of Texas at Austin College of Pharmacy, Austin, Texas, USA; 2University of the Incarnate Word Feik School of Pharmacy, San Antonio, Texas, USAAbstract: Micafungin is an echinocandin antifungal agent available for clinical use in Japan, Europe, and the United States. Through inhibition of β-1,3-glucan production, an essential component of the fungal cell wall, micafungin exhibits potent antifungal activity against key pathogenic fungi, including Candida and Aspergillus species, while contributing minimal toxicity to mammalian cells. This activity is maintained against polyene and azole-resistant isolates. Pharmacokinetic and pharmacodynamic studies have demonstrated linear kinetics both in adults and children with concentration-dependent activity observed both in vitro and in vivo. Dosage escalation studies have also demonstrated that doses much higher than those currently recommended may be administered without serious adverse effects. Clinically, micafungin has been shown to be efficacious for the treatment of invasive candidiasis and invasive aspergillosis. Furthermore, the clinical effectiveness of micafungin against these infections occurs without the drug interactions that occur with the azoles and the nephrotoxicity observed with amphotericin B formulations. This review will focus on the pharmacology, clinical microbiology, mechanisms of resistance, safety, and clinical efficacy of micafungin in the treatment of invasive candidiasis and invasive aspergillosis.Keywords: micafungin, echinocandin, Candida, Aspergillus, invasive candidiasis, invasive aspergillosis |
| first_indexed | 2024-04-13T17:20:20Z |
| format | Article |
| id | doaj.art-55f7053ecbe94b5c93a90bb95a912582 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T17:20:20Z |
| publishDate | 2009-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-55f7053ecbe94b5c93a90bb95a9125822022-12-22T02:38:01ZengDove Medical PressInfection and Drug Resistance1178-69732009-01-012008default6377Micafungin in the treatment of invasive candidiasis and invasive aspergillosisNathan P WiederholdJason M CotaChristopher R FreiNathan P Wiederhold1, Jason M Cota2, Christopher R Frei11University of Texas at Austin College of Pharmacy, Austin, Texas, USA; 2University of the Incarnate Word Feik School of Pharmacy, San Antonio, Texas, USAAbstract: Micafungin is an echinocandin antifungal agent available for clinical use in Japan, Europe, and the United States. Through inhibition of β-1,3-glucan production, an essential component of the fungal cell wall, micafungin exhibits potent antifungal activity against key pathogenic fungi, including Candida and Aspergillus species, while contributing minimal toxicity to mammalian cells. This activity is maintained against polyene and azole-resistant isolates. Pharmacokinetic and pharmacodynamic studies have demonstrated linear kinetics both in adults and children with concentration-dependent activity observed both in vitro and in vivo. Dosage escalation studies have also demonstrated that doses much higher than those currently recommended may be administered without serious adverse effects. Clinically, micafungin has been shown to be efficacious for the treatment of invasive candidiasis and invasive aspergillosis. Furthermore, the clinical effectiveness of micafungin against these infections occurs without the drug interactions that occur with the azoles and the nephrotoxicity observed with amphotericin B formulations. This review will focus on the pharmacology, clinical microbiology, mechanisms of resistance, safety, and clinical efficacy of micafungin in the treatment of invasive candidiasis and invasive aspergillosis.Keywords: micafungin, echinocandin, Candida, Aspergillus, invasive candidiasis, invasive aspergillosishttp://www.dovepress.com/micafungin-in-the-treatment-of-invasive-candidiasis-and-invasive-asper-a2784 |
| spellingShingle | Nathan P Wiederhold Jason M Cota Christopher R Frei Micafungin in the treatment of invasive candidiasis and invasive aspergillosis Infection and Drug Resistance |
| title | Micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| title_full | Micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| title_fullStr | Micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| title_full_unstemmed | Micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| title_short | Micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| title_sort | micafungin in the treatment of invasive candidiasis and invasive aspergillosis |
| url | http://www.dovepress.com/micafungin-in-the-treatment-of-invasive-candidiasis-and-invasive-asper-a2784 |
| work_keys_str_mv | AT nathanpwiederhold micafungininthetreatmentofinvasivecandidiasisandinvasiveaspergillosis AT jasonmcota micafungininthetreatmentofinvasivecandidiasisandinvasiveaspergillosis AT christopherrfrei micafungininthetreatmentofinvasivecandidiasisandinvasiveaspergillosis |