TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels
Anesthesia with propofol is frequently associated with hypotension. The <i>TRPA1</i> gene contributes to the vasodilator effect of propofol. Hypotension is crucial for anesthesiologists because it is deleterious in the perioperative period. We tested whether the <i>TRPA1</i>...
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| Format: | Article |
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2022-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/12/432 |
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| author | Isabela Borges de Melo Gustavo H. Oliveira-Paula Letícia Perticarrara Ferezin Graziele C. Ferreira Lucas C. Pinheiro Jose E. Tanus-Santos Luis V. Garcia Riccardo Lacchini Waynice N. Paula-Garcia |
| author_facet | Isabela Borges de Melo Gustavo H. Oliveira-Paula Letícia Perticarrara Ferezin Graziele C. Ferreira Lucas C. Pinheiro Jose E. Tanus-Santos Luis V. Garcia Riccardo Lacchini Waynice N. Paula-Garcia |
| author_sort | Isabela Borges de Melo |
| collection | DOAJ |
| description | Anesthesia with propofol is frequently associated with hypotension. The <i>TRPA1</i> gene contributes to the vasodilator effect of propofol. Hypotension is crucial for anesthesiologists because it is deleterious in the perioperative period. We tested whether the <i>TRPA1</i> gene polymorphisms or haplotypes interfere with the hypotensive responses to propofol. PCR-determined genotypes and haplotype frequencies were estimated. Nitrite, nitrates, and NOx levels were measured. Propofol induced a more expressive lowering of the blood pressure (BP) without changing nitrite or nitrate levels in patients carrying CG+GG genotypes for the rs16937976 TRPA1 polymorphism and AG+AA genotypes for the rs13218757 TRPA1 polymorphism. The CGA haplotype presented the most remarkable drop in BP. Heart rate values were not impacted. The present exploratory analysis suggests that TRPA1 genotypes and haplotypes influence the hypotensive responses to propofol. The mechanisms involved are probably other than those related to NO bioavailability. With better genetic knowledge, planning anesthesia with fewer side effects may be possible. |
| first_indexed | 2024-03-09T17:11:21Z |
| format | Article |
| id | doaj.art-55f7357cd361491e83bd72a8b116dc44 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T17:11:21Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-55f7357cd361491e83bd72a8b116dc442023-11-24T14:03:57ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-12-0144126333634510.3390/cimb44120432TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate LevelsIsabela Borges de Melo0Gustavo H. Oliveira-Paula1Letícia Perticarrara Ferezin2Graziele C. Ferreira3Lucas C. Pinheiro4Jose E. Tanus-Santos5Luis V. Garcia6Riccardo Lacchini7Waynice N. Paula-Garcia8Department of Orthopedics and Anesthesiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Orthopedics and Anesthesiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilDepartment of Orthopedics and Anesthesiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14048900, SP, BrazilAnesthesia with propofol is frequently associated with hypotension. The <i>TRPA1</i> gene contributes to the vasodilator effect of propofol. Hypotension is crucial for anesthesiologists because it is deleterious in the perioperative period. We tested whether the <i>TRPA1</i> gene polymorphisms or haplotypes interfere with the hypotensive responses to propofol. PCR-determined genotypes and haplotype frequencies were estimated. Nitrite, nitrates, and NOx levels were measured. Propofol induced a more expressive lowering of the blood pressure (BP) without changing nitrite or nitrate levels in patients carrying CG+GG genotypes for the rs16937976 TRPA1 polymorphism and AG+AA genotypes for the rs13218757 TRPA1 polymorphism. The CGA haplotype presented the most remarkable drop in BP. Heart rate values were not impacted. The present exploratory analysis suggests that TRPA1 genotypes and haplotypes influence the hypotensive responses to propofol. The mechanisms involved are probably other than those related to NO bioavailability. With better genetic knowledge, planning anesthesia with fewer side effects may be possible.https://www.mdpi.com/1467-3045/44/12/432propofolTRPA1adverse drug reactionsblood pressuregenetic polymorphismsnitric oxide |
| spellingShingle | Isabela Borges de Melo Gustavo H. Oliveira-Paula Letícia Perticarrara Ferezin Graziele C. Ferreira Lucas C. Pinheiro Jose E. Tanus-Santos Luis V. Garcia Riccardo Lacchini Waynice N. Paula-Garcia TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels Current Issues in Molecular Biology propofol TRPA1 adverse drug reactions blood pressure genetic polymorphisms nitric oxide |
| title | TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels |
| title_full | TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels |
| title_fullStr | TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels |
| title_full_unstemmed | TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels |
| title_short | TRPA1 Polymorphisms Modify the Hypotensive Responses to Propofol with No Change in Nitrite or Nitrate Levels |
| title_sort | trpa1 polymorphisms modify the hypotensive responses to propofol with no change in nitrite or nitrate levels |
| topic | propofol TRPA1 adverse drug reactions blood pressure genetic polymorphisms nitric oxide |
| url | https://www.mdpi.com/1467-3045/44/12/432 |
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