Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group
Abstract Leukemia burden is growing in the Gulf Council Cooperation (GCC) countries. Nonetheless, there is no unified protocol for managing adult acute lymphoblastic leukemia (ALL) patients in the GCC‐countries. Therefore, the GCC Adult‐ALL Treaters working group developed this consensus to address...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1931 |
| _version_ | 1797292545285292032 |
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| author | Feras Alfraih Ahmed Absi Mohamed Abuhaleeqa Khalofa Alghamdi Ahmad Alhuraiji Murtadha Al‐Khabori Zeyad Al‐Shaibani Musa Alzahrani Honar Cherif Saleem Eldadah Amr Hanbali Ibraheem H. Motabi Hind Salama |
| author_facet | Feras Alfraih Ahmed Absi Mohamed Abuhaleeqa Khalofa Alghamdi Ahmad Alhuraiji Murtadha Al‐Khabori Zeyad Al‐Shaibani Musa Alzahrani Honar Cherif Saleem Eldadah Amr Hanbali Ibraheem H. Motabi Hind Salama |
| author_sort | Feras Alfraih |
| collection | DOAJ |
| description | Abstract Leukemia burden is growing in the Gulf Council Cooperation (GCC) countries. Nonetheless, there is no unified protocol for managing adult acute lymphoblastic leukemia (ALL) patients in the GCC‐countries. Therefore, the GCC Adult‐ALL Treaters working group developed this consensus to address the adult‐ALL treatment protocols in the GCC‐countries and related toxicities' management. Besides, the consensus aimed to highlight the current unmet needs and treatment gaps and provide recommendations to optimize adult‐ALL care and patient‐centered communication. A three‐step modified Delphi method to develop evidence‐based recommendations through two‐voting rounds and in‐between virtual meetings are used in the manuscript development. A 12 experts' panel from five GCC‐countries and two international experts were invited to participate in this consensus. This consensus consisted of 35‐statements that highlighted the experts' recommendations to optimize ALL adults' care in the first line setting and manage pediatric or pediatric‐inspired regimens‐related toxicities. Besides, guidance was provided for future research direction and improve patient‐centered communication. In conclusion, the adult‐ALL management landscape is evolving, and the current evidence highlights better response and survival outcomes with pediatric or pediatric‐inspired regiments. Therefore, protocols are needed to optimize the adult‐ALL management in the GCC and tailored clinical‐trials findings according to the GCC patients' characteristics and local‐healthcare infrastructure. |
| first_indexed | 2024-03-07T19:57:58Z |
| format | Article |
| id | doaj.art-55f760154b6946a78d38acd42823c57f |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-07T19:57:58Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-55f760154b6946a78d38acd42823c57f2024-02-28T13:54:58ZengWileyCancer Reports2573-83482024-02-0172n/an/a10.1002/cnr2.1931Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working GroupFeras Alfraih0Ahmed Absi1Mohamed Abuhaleeqa2Khalofa Alghamdi3Ahmad Alhuraiji4Murtadha Al‐Khabori5Zeyad Al‐Shaibani6Musa Alzahrani7Honar Cherif8Saleem Eldadah9Amr Hanbali10Ibraheem H. Motabi11Hind Salama12King Faisal Specialist Hospital and Research Centre Riyadh Saudi ArabiaPrincess Noorah Oncology Center King Abdulaziz Medical City, Ministry of National Guard Health Affairs Jeddah Saudi ArabiaAbu Dhabi Stem Cells Center Abu Dhabi UAEKing Abdullah Medical City Makkah Saudi ArabiaDepartment of Hematology Kuwait Cancer Control Center Kuwait City KuwaitDepartment of Hematology, College of Medicine and Health Sciences Sultan Qaboos University Muscat OmanKing Faisal Specialist Hospital and Research Centre Madinah Saudi ArabiaDepartment of Medicine, College of Medicine King Saud University Riyadh Saudi ArabiaNational Center for Cancer Care and Research Hamad Medical Cooperation Doha QatarPrincess Noorah Oncology Center King Abdulaziz Medical City, Ministry of National Guard Health Affairs Jeddah Saudi ArabiaKing Faisal Specialist Hospital and Research Centre Riyadh Saudi ArabiaKing Fahad Medical City Department of Adult Hematology and BMTKing Abdulaziz‐Medical City Riyadh Saudi ArabiaAbstract Leukemia burden is growing in the Gulf Council Cooperation (GCC) countries. Nonetheless, there is no unified protocol for managing adult acute lymphoblastic leukemia (ALL) patients in the GCC‐countries. Therefore, the GCC Adult‐ALL Treaters working group developed this consensus to address the adult‐ALL treatment protocols in the GCC‐countries and related toxicities' management. Besides, the consensus aimed to highlight the current unmet needs and treatment gaps and provide recommendations to optimize adult‐ALL care and patient‐centered communication. A three‐step modified Delphi method to develop evidence‐based recommendations through two‐voting rounds and in‐between virtual meetings are used in the manuscript development. A 12 experts' panel from five GCC‐countries and two international experts were invited to participate in this consensus. This consensus consisted of 35‐statements that highlighted the experts' recommendations to optimize ALL adults' care in the first line setting and manage pediatric or pediatric‐inspired regimens‐related toxicities. Besides, guidance was provided for future research direction and improve patient‐centered communication. In conclusion, the adult‐ALL management landscape is evolving, and the current evidence highlights better response and survival outcomes with pediatric or pediatric‐inspired regiments. Therefore, protocols are needed to optimize the adult‐ALL management in the GCC and tailored clinical‐trials findings according to the GCC patients' characteristics and local‐healthcare infrastructure.https://doi.org/10.1002/cnr2.1931acute lymphoblastic leukemiaadultchemotherapyconsensusstandard of care |
| spellingShingle | Feras Alfraih Ahmed Absi Mohamed Abuhaleeqa Khalofa Alghamdi Ahmad Alhuraiji Murtadha Al‐Khabori Zeyad Al‐Shaibani Musa Alzahrani Honar Cherif Saleem Eldadah Amr Hanbali Ibraheem H. Motabi Hind Salama Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group Cancer Reports acute lymphoblastic leukemia adult chemotherapy consensus standard of care |
| title | Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group |
| title_full | Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group |
| title_fullStr | Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group |
| title_full_unstemmed | Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group |
| title_short | Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group |
| title_sort | management of adult acute lymphoblastic leukemia in the gulf cooperation council gcc countries a consensus report from the gcc adult all working group |
| topic | acute lymphoblastic leukemia adult chemotherapy consensus standard of care |
| url | https://doi.org/10.1002/cnr2.1931 |
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