Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report
Abstract Background Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome. Case presentation We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-021-02835-0 |
| _version_ | 1818607487576702976 |
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| author | Roya Farhadi Shahrokh Mehrpisheh Vajiheh Ghaffari Mohammadreza Haghshenas Aghdas Ebadi |
| author_facet | Roya Farhadi Shahrokh Mehrpisheh Vajiheh Ghaffari Mohammadreza Haghshenas Aghdas Ebadi |
| author_sort | Roya Farhadi |
| collection | DOAJ |
| description | Abstract Background Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome. Case presentation We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumonia. The mother underwent cesarean delivery, and amniotic fluid yielded a positive result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR). The newborn infant showed early-onset infection with SARS-CoV-2 confirmed on pharyngeal swabs by RT-PCR assay within 24 hours after birth, suggesting vertical transmission. Unfortunately, the mother died 14 days after delivery. We describe the clinical course and outcome of the infant up to 7 months of age. Conclusion COVID-19 infection in pregnant women may increase maternal morbidity, mortality and possibly vertical transmission in severe cases. However, it does not seem to progress to serious early or late neonatal complications. |
| first_indexed | 2024-12-16T14:27:32Z |
| format | Article |
| id | doaj.art-55f91a39f7f247b8a832f5d29117d815 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-16T14:27:32Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-55f91a39f7f247b8a832f5d29117d8152022-12-21T22:28:20ZengBMCJournal of Medical Case Reports1752-19472021-04-011511510.1186/s13256-021-02835-0Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case reportRoya Farhadi0Shahrokh Mehrpisheh1Vajiheh Ghaffari2Mohammadreza Haghshenas3Aghdas Ebadi4Pediatrics infectious diseases research center, Mazandaran University of Medical SciencesPediatrics infectious diseases research center, Mazandaran University of Medical SciencesPediatrics infectious diseases research center, Mazandaran University of Medical SciencesMolecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical SciencesDepartment of Obstetrics and Gynecology, Mazandaran University of Medical SciencesAbstract Background Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome. Case presentation We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumonia. The mother underwent cesarean delivery, and amniotic fluid yielded a positive result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR). The newborn infant showed early-onset infection with SARS-CoV-2 confirmed on pharyngeal swabs by RT-PCR assay within 24 hours after birth, suggesting vertical transmission. Unfortunately, the mother died 14 days after delivery. We describe the clinical course and outcome of the infant up to 7 months of age. Conclusion COVID-19 infection in pregnant women may increase maternal morbidity, mortality and possibly vertical transmission in severe cases. However, it does not seem to progress to serious early or late neonatal complications.https://doi.org/10.1186/s13256-021-02835-0COVID-19SARS-CoV-2NeonatePreterm infantVertical transmission |
| spellingShingle | Roya Farhadi Shahrokh Mehrpisheh Vajiheh Ghaffari Mohammadreza Haghshenas Aghdas Ebadi Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report Journal of Medical Case Reports COVID-19 SARS-CoV-2 Neonate Preterm infant Vertical transmission |
| title | Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report |
| title_full | Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report |
| title_fullStr | Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report |
| title_full_unstemmed | Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report |
| title_short | Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report |
| title_sort | clinical course radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe covid 19 pneumonia a case report |
| topic | COVID-19 SARS-CoV-2 Neonate Preterm infant Vertical transmission |
| url | https://doi.org/10.1186/s13256-021-02835-0 |
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