Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases
Abstract Background Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) has been reported worldwidely. However, the data about recurrent cases is limited. We aimed to analyze the clinical and radiographic features of recurrent MERS, and its possible mechanisms. Case presentatio...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-021-03097-x |
| _version_ | 1819229253879726080 |
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| author | Jiao Xue Chongfeng Duan Guizhi Xu Ying Zhang Zhenfeng Song Zhi Yi Chengqing Yang Fei Li Kaixuan Liu Hongshan Zhao Xuejun Liu |
| author_facet | Jiao Xue Chongfeng Duan Guizhi Xu Ying Zhang Zhenfeng Song Zhi Yi Chengqing Yang Fei Li Kaixuan Liu Hongshan Zhao Xuejun Liu |
| author_sort | Jiao Xue |
| collection | DOAJ |
| description | Abstract Background Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) has been reported worldwidely. However, the data about recurrent cases is limited. We aimed to analyze the clinical and radiographic features of recurrent MERS, and its possible mechanisms. Case presentation Two patients with clinically recurrent MERS were reported here, exhibiting neurological symptoms such as limbs weakness and numbness, stand/walk unsteadily, slurred speech and irritability, and typical lesions in the corpus callosum and white matter. One of them experienced another four episodes with a similar clinical course and magnetic resonance imaging findings over a period of 10 years. The Na levels in the present two patients were normal. Discussion and conclusion Combined with the patients reported previously, recurrence could be seen in both MERS type 1 and type 2 patients, from two to multiple times, with the latter possibly more common. It suggested that some genetic factors might be involved in MERS, especially for MERS type 2 or familial MERS. |
| first_indexed | 2024-12-23T11:10:15Z |
| format | Article |
| id | doaj.art-55f9264fc30a4605b953b5763c70330f |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-23T11:10:15Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-55f9264fc30a4605b953b5763c70330f2022-12-21T17:49:21ZengBMCBMC Pediatrics1471-24312022-01-012211610.1186/s12887-021-03097-xClinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two casesJiao Xue0Chongfeng Duan1Guizhi Xu2Ying Zhang3Zhenfeng Song4Zhi Yi5Chengqing Yang6Fei Li7Kaixuan Liu8Hongshan Zhao9Xuejun Liu10Department of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Radiology, the Affiliated Hospital of Qingdao UniversityDepartment of Radiology, Zhucheng People HospitalDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Pediatric Neurology, the Affiliated Hospital of Qingdao UniversityDepartment of Anesthesiology, the Affiliated Hospital of Qingdao UniversityDepartment of Radiology, the Affiliated Hospital of Qingdao UniversityAbstract Background Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) has been reported worldwidely. However, the data about recurrent cases is limited. We aimed to analyze the clinical and radiographic features of recurrent MERS, and its possible mechanisms. Case presentation Two patients with clinically recurrent MERS were reported here, exhibiting neurological symptoms such as limbs weakness and numbness, stand/walk unsteadily, slurred speech and irritability, and typical lesions in the corpus callosum and white matter. One of them experienced another four episodes with a similar clinical course and magnetic resonance imaging findings over a period of 10 years. The Na levels in the present two patients were normal. Discussion and conclusion Combined with the patients reported previously, recurrence could be seen in both MERS type 1 and type 2 patients, from two to multiple times, with the latter possibly more common. It suggested that some genetic factors might be involved in MERS, especially for MERS type 2 or familial MERS.https://doi.org/10.1186/s12887-021-03097-xChildRecurrentMERS |
| spellingShingle | Jiao Xue Chongfeng Duan Guizhi Xu Ying Zhang Zhenfeng Song Zhi Yi Chengqing Yang Fei Li Kaixuan Liu Hongshan Zhao Xuejun Liu Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases BMC Pediatrics Child Recurrent MERS |
| title | Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases |
| title_full | Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases |
| title_fullStr | Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases |
| title_full_unstemmed | Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases |
| title_short | Clinical study of recurrent mild encephalitis/encephalopathy with a reversible splenial lesion in two cases |
| title_sort | clinical study of recurrent mild encephalitis encephalopathy with a reversible splenial lesion in two cases |
| topic | Child Recurrent MERS |
| url | https://doi.org/10.1186/s12887-021-03097-x |
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