Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

Abstract Background Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson’s disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of the effects of the environmental toxicant, paraquat, t...

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Bibliographic Details
Main Authors: Chris Rudyk, Zach Dwyer, Shawn Hayley, CLINT membership
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s
LRRK2
Inflammatory
Microglia
Cytokine
Toxicity
Online Access:http://link.springer.com/article/10.1186/s12974-019-1483-7

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http://link.springer.com/article/10.1186/s12974-019-1483-7

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