Prospects for the Use of ATR Inhibitors to Treat Cancer
ATR is an apical kinase in one of the DNA-damage induced checkpoint pathways. Despite the development of inhibitors of kinases structurally related to ATR, as well as inhibitors of the ATR substrate Chk1, no ATR inhibitors have yet been developed. Here we review the effects of ATR downregulation in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-04-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8247/3/5/1311/ |
| _version_ | 1811279721226305536 |
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| author | Scott H. Kaufmann Jill M. Wagner |
| author_facet | Scott H. Kaufmann Jill M. Wagner |
| author_sort | Scott H. Kaufmann |
| collection | DOAJ |
| description | ATR is an apical kinase in one of the DNA-damage induced checkpoint pathways. Despite the development of inhibitors of kinases structurally related to ATR, as well as inhibitors of the ATR substrate Chk1, no ATR inhibitors have yet been developed. Here we review the effects of ATR downregulation in cancer cells and discuss the potential for development of ATR inhibitors for clinical use. |
| first_indexed | 2024-04-13T01:00:46Z |
| format | Article |
| id | doaj.art-55faf402b8954167a7887ccd963b4ed5 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-13T01:00:46Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-55faf402b8954167a7887ccd963b4ed52022-12-22T03:09:29ZengMDPI AGPharmaceuticals1424-82472010-04-01351311133410.3390/ph3051311Prospects for the Use of ATR Inhibitors to Treat CancerScott H. KaufmannJill M. WagnerATR is an apical kinase in one of the DNA-damage induced checkpoint pathways. Despite the development of inhibitors of kinases structurally related to ATR, as well as inhibitors of the ATR substrate Chk1, no ATR inhibitors have yet been developed. Here we review the effects of ATR downregulation in cancer cells and discuss the potential for development of ATR inhibitors for clinical use.http://www.mdpi.com/1424-8247/3/5/1311/Replication checkpointATRATMchemotherapyChk1 |
| spellingShingle | Scott H. Kaufmann Jill M. Wagner Prospects for the Use of ATR Inhibitors to Treat Cancer Pharmaceuticals Replication checkpoint ATR ATM chemotherapy Chk1 |
| title | Prospects for the Use of ATR Inhibitors to Treat Cancer |
| title_full | Prospects for the Use of ATR Inhibitors to Treat Cancer |
| title_fullStr | Prospects for the Use of ATR Inhibitors to Treat Cancer |
| title_full_unstemmed | Prospects for the Use of ATR Inhibitors to Treat Cancer |
| title_short | Prospects for the Use of ATR Inhibitors to Treat Cancer |
| title_sort | prospects for the use of atr inhibitors to treat cancer |
| topic | Replication checkpoint ATR ATM chemotherapy Chk1 |
| url | http://www.mdpi.com/1424-8247/3/5/1311/ |
| work_keys_str_mv | AT scotthkaufmann prospectsfortheuseofatrinhibitorstotreatcancer AT jillmwagner prospectsfortheuseofatrinhibitorstotreatcancer |