Oncogenic Kras initiates leukemia in hematopoietic stem cells.

Oncogenic Kras initiates leukemia in hematopoietic stem cells.

How oncogenes modulate the self-renewal properties of cancer-initiating cells is incompletely understood. Activating KRAS and NRAS mutations are among the most common oncogenic lesions detected in human cancer, and occur in myeloproliferative disorders (MPDs) and leukemias. We investigated the effec...

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Bibliographic Details
Main Authors: Amit J Sabnis, Laurene S Cheung, Monique Dail, Hio Chung Kang, Marianne Santaguida, Michelle L Hermiston, Emmanuelle Passegué, Kevin Shannon, Benjamin S Braun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2656550?pdf=render

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