Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor
Angiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, RAS). AngII, a main biopolypeptide of the RAS, has important pathophysiologic in effects participating in cardiac hypertrophy, vascular cell...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-09-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.09.10 |
| _version_ | 1818421819789541376 |
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| author | Lulu SUN Jian SHI |
| author_facet | Lulu SUN Jian SHI |
| author_sort | Lulu SUN |
| collection | DOAJ |
| description | Angiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, RAS). AngII, a main biopolypeptide of the RAS, has important pathophysiologic in effects participating in cardiac hypertrophy, vascular cell proproliferation, inflammation and tissue remodeling through G-protein-coupled receptors. In recent years, Ang II can promote tumor cell proliferation, tumor vessel formation and inhibit the differentiation of the tumor cells. This suggests that inhibit the production of AngII or block its effect is expected to become a new measure for the treatment of malignant tumors. This article reviews the advances in research on the relationship between AngII and its receptor and malignant tumor in recent years. |
| first_indexed | 2024-12-14T13:16:25Z |
| format | Article |
| id | doaj.art-55fb3f86d78c486a9da194a1f778d58e |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-14T13:16:25Z |
| publishDate | 2016-09-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-55fb3f86d78c486a9da194a1f778d58e2022-12-21T23:00:02ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-09-0119961561910.3779/j.issn.1009-3419.2016.09.10Advance in Research of Angiotensin II and Its Receptor and Malignant TumorLulu SUN0Jian SHI1Graduate Student of Hebei Medical University, Shijiazhuang 050000, ChinaDepartment of Medical Oncology, Hebei Province Cancer Hospital, Shijiazhuang 050000, ChinaAngiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, RAS). AngII, a main biopolypeptide of the RAS, has important pathophysiologic in effects participating in cardiac hypertrophy, vascular cell proproliferation, inflammation and tissue remodeling through G-protein-coupled receptors. In recent years, Ang II can promote tumor cell proliferation, tumor vessel formation and inhibit the differentiation of the tumor cells. This suggests that inhibit the production of AngII or block its effect is expected to become a new measure for the treatment of malignant tumors. This article reviews the advances in research on the relationship between AngII and its receptor and malignant tumor in recent years.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.09.10TumorAngiotensin IIAngiotensin II 1 receptorAngiotensin II 2 receptor |
| spellingShingle | Lulu SUN Jian SHI Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor Chinese Journal of Lung Cancer Tumor Angiotensin II Angiotensin II 1 receptor Angiotensin II 2 receptor |
| title | Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor |
| title_full | Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor |
| title_fullStr | Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor |
| title_full_unstemmed | Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor |
| title_short | Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor |
| title_sort | advance in research of angiotensin ii and its receptor and malignant tumor |
| topic | Tumor Angiotensin II Angiotensin II 1 receptor Angiotensin II 2 receptor |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.09.10 |
| work_keys_str_mv | AT lulusun advanceinresearchofangiotensiniianditsreceptorandmalignanttumor AT jianshi advanceinresearchofangiotensiniianditsreceptorandmalignanttumor |