Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research
Abstract Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss, and disability, is a common musculoskeletal disorder that results in significant socioeconomic burdens. Despite extensive clinical and basic scientific research efforts, herniation etiopathogenesi...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | JOR Spine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jsp2.1289 |
| _version_ | 1827308472642830336 |
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| author | Minhao Zhou Alekos A. Theologis Grace D. O’Connell |
| author_facet | Minhao Zhou Alekos A. Theologis Grace D. O’Connell |
| author_sort | Minhao Zhou |
| collection | DOAJ |
| description | Abstract Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss, and disability, is a common musculoskeletal disorder that results in significant socioeconomic burdens. Despite extensive clinical and basic scientific research efforts, herniation etiopathogenesis, particularly its initiation and progression, is not well understood. Understanding herniation etiopathogenesis is essential for developing effective preventive measures and therapeutic interventions. Thus, this review seeks to provide a thorough overview of the advances in herniation‐oriented research, with a discussion on ongoing challenges and potential future directions for clinical, translational, and basic scientific investigations to facilitate innovative interdisciplinary research aimed at understanding herniation etiopathogenesis. Specifically, risk factors for herniation are identified and summarized, including familial predisposition, obesity, diabetes mellitus, smoking tobacco, selected cardiovascular diseases, disc degeneration, and occupational risks. Basic scientific experimental and computational research that aims to understand the link between excessive mechanical load, catabolic tissue remodeling due to inflammation or insufficient nutrient supply, and herniation, are also reviewed. Potential future directions to address the current challenges in herniation‐oriented research are explored by combining known progressive development in existing research techniques with ongoing technological advances. More research on the relationship between occupational risk factors and herniation, as well as the relationship between degeneration and herniation, is needed to develop preventive measures for working‐age individuals. Notably, researchers should explore using or modifying existing degeneration animal models to study herniation etiopathogenesis, as such models may allow for a better understanding of how to prevent mild‐to‐moderately degenerated discs from herniating. |
| first_indexed | 2024-04-24T19:08:17Z |
| format | Article |
| id | doaj.art-55ff0e37ce364895aa1d892d6f39ce88 |
| institution | Directory Open Access Journal |
| issn | 2572-1143 |
| language | English |
| last_indexed | 2024-04-24T19:08:17Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | JOR Spine |
| spelling | doaj.art-55ff0e37ce364895aa1d892d6f39ce882024-03-26T14:08:39ZengWileyJOR Spine2572-11432024-03-0171n/an/a10.1002/jsp2.1289Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific researchMinhao Zhou0Alekos A. Theologis1Grace D. O’Connell2Department of Mechanical Engineering University of California, Berkeley (UC Berkeley) Berkeley California USADepartment of Orthopaedic Surgery University of California, San Francisco (UCSF) San Francisco California USADepartment of Mechanical Engineering University of California, Berkeley (UC Berkeley) Berkeley California USAAbstract Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss, and disability, is a common musculoskeletal disorder that results in significant socioeconomic burdens. Despite extensive clinical and basic scientific research efforts, herniation etiopathogenesis, particularly its initiation and progression, is not well understood. Understanding herniation etiopathogenesis is essential for developing effective preventive measures and therapeutic interventions. Thus, this review seeks to provide a thorough overview of the advances in herniation‐oriented research, with a discussion on ongoing challenges and potential future directions for clinical, translational, and basic scientific investigations to facilitate innovative interdisciplinary research aimed at understanding herniation etiopathogenesis. Specifically, risk factors for herniation are identified and summarized, including familial predisposition, obesity, diabetes mellitus, smoking tobacco, selected cardiovascular diseases, disc degeneration, and occupational risks. Basic scientific experimental and computational research that aims to understand the link between excessive mechanical load, catabolic tissue remodeling due to inflammation or insufficient nutrient supply, and herniation, are also reviewed. Potential future directions to address the current challenges in herniation‐oriented research are explored by combining known progressive development in existing research techniques with ongoing technological advances. More research on the relationship between occupational risk factors and herniation, as well as the relationship between degeneration and herniation, is needed to develop preventive measures for working‐age individuals. Notably, researchers should explore using or modifying existing degeneration animal models to study herniation etiopathogenesis, as such models may allow for a better understanding of how to prevent mild‐to‐moderately degenerated discs from herniating.https://doi.org/10.1002/jsp2.1289biomechanicsinjurystructure–function relationships |
| spellingShingle | Minhao Zhou Alekos A. Theologis Grace D. O’Connell Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research JOR Spine biomechanics injury structure–function relationships |
| title | Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research |
| title_full | Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research |
| title_fullStr | Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research |
| title_full_unstemmed | Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research |
| title_short | Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research |
| title_sort | understanding the etiopathogenesis of lumbar intervertebral disc herniation from clinical evidence to basic scientific research |
| topic | biomechanics injury structure–function relationships |
| url | https://doi.org/10.1002/jsp2.1289 |
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