In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity

In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity

Abstract Background Glycol chitosan nanoparticles (CNPs) have emerged as an effective drug delivery system for cancer diagnosis and treatment. Although they have great biocompatibility owing to biodegradable chemical structure and low immunogenicity, sufficient information on in vivo toxicity to und...

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Bibliographic Details
Main Authors: Hyeyoun Chang, Ji Young Yhee, Sangmin Jeon, Man Kyu Shim, Hong Yeol Yoon, Sangmin Lee, Kwangmeyung Kim
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Glycol chitosan nanoparticles
Nanotoxicology
Toxicity evaluation
Cardiotoxicity
Online Access:https://doi.org/10.1186/s12951-023-01824-3

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