Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery
Lipid and protein-based delivery systems have long been used to deliver active compounds such as drugs, genes, and nutraceuticals. These delivery systems are fabricated to overcome issues of pure active compounds, which include rapid release and metabolism, poor solubility, low stability, poor bioav...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Food Hydrocolloids for Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025922000024 |
| _version_ | 1828174529665433600 |
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| author | Thilini Dissanayake Xiaohong Sun Lord Abbey Nandika Bandara |
| author_facet | Thilini Dissanayake Xiaohong Sun Lord Abbey Nandika Bandara |
| author_sort | Thilini Dissanayake |
| collection | DOAJ |
| description | Lipid and protein-based delivery systems have long been used to deliver active compounds such as drugs, genes, and nutraceuticals. These delivery systems are fabricated to overcome issues of pure active compounds, which include rapid release and metabolism, poor solubility, low stability, poor bioavailability, poor bioaccessibility, and toxicity. However, there are limitations of lipids and proteins that restrict their efficient use in the delivery systems. Lipid-protein conjugation is an emerging technique for fabricating novel delivery systems that provide the advantages of having both proteins and lipids in one delivery system. In addition, these conjugates have a much better synergistic effect and desirable properties inside the body than single carriers. Among them, colloidal and biological stability, enhanced mechanical strength, controlled release, higher circulation time, targeted delivery, less cytotoxicity, higher loading capacity, co-encapsulation, and enhanced bioavailability are key outcomes. Despite recent technological advancement, there are still drawbacks to lipid-protein conjugate-based delivery systems that should be addressed in future research studies. This review is focused on critically evaluating the importance of lipid and protein as delivery systems, benefits of lipid-protein conjugation, conjugation methods, various applications of lipid-protein conjugation in drugs, genes, and nutraceutical delivery, and identifying research challenges and future research directions. |
| first_indexed | 2024-04-12T04:14:24Z |
| format | Article |
| id | doaj.art-56032081764943be96fcdbf0cf071272 |
| institution | Directory Open Access Journal |
| issn | 2667-0259 |
| language | English |
| last_indexed | 2024-04-12T04:14:24Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj.art-56032081764943be96fcdbf0cf0712722022-12-22T03:48:26ZengElsevierFood Hydrocolloids for Health2667-02592022-12-012100054Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene deliveryThilini Dissanayake0Xiaohong Sun1Lord Abbey2Nandika Bandara3Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg R3T 2N2, Canada; Richardson Centre for Food Technology and Research (RCFTR), 196, Innovation Drive, Winnipeg, Manitoba R3T 6C5 CanadaCollege of Food and Biological Engineering, Qiqihar University, Qiqihar, Heilongjiang 161006, ChinaDepartment of Plant, Food & Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, CanadaDepartment of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg R3T 2N2, Canada; Richardson Centre for Food Technology and Research (RCFTR), 196, Innovation Drive, Winnipeg, Manitoba R3T 6C5 Canada; Department of Plant, Food & Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada; Corresponding author at: Richardson Centre for Functional Foods and Nutraceuticals, 196, Innovation Drive, Winnipeg, Manitoba R3T 2N2. Canada.Lipid and protein-based delivery systems have long been used to deliver active compounds such as drugs, genes, and nutraceuticals. These delivery systems are fabricated to overcome issues of pure active compounds, which include rapid release and metabolism, poor solubility, low stability, poor bioavailability, poor bioaccessibility, and toxicity. However, there are limitations of lipids and proteins that restrict their efficient use in the delivery systems. Lipid-protein conjugation is an emerging technique for fabricating novel delivery systems that provide the advantages of having both proteins and lipids in one delivery system. In addition, these conjugates have a much better synergistic effect and desirable properties inside the body than single carriers. Among them, colloidal and biological stability, enhanced mechanical strength, controlled release, higher circulation time, targeted delivery, less cytotoxicity, higher loading capacity, co-encapsulation, and enhanced bioavailability are key outcomes. Despite recent technological advancement, there are still drawbacks to lipid-protein conjugate-based delivery systems that should be addressed in future research studies. This review is focused on critically evaluating the importance of lipid and protein as delivery systems, benefits of lipid-protein conjugation, conjugation methods, various applications of lipid-protein conjugation in drugs, genes, and nutraceutical delivery, and identifying research challenges and future research directions.http://www.sciencedirect.com/science/article/pii/S2667025922000024Lipid-protein conjugationDrug deliveryGene deliveryNutraceutical deliveryBioavailability |
| spellingShingle | Thilini Dissanayake Xiaohong Sun Lord Abbey Nandika Bandara Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery Food Hydrocolloids for Health Lipid-protein conjugation Drug delivery Gene delivery Nutraceutical delivery Bioavailability |
| title | Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery |
| title_full | Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery |
| title_fullStr | Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery |
| title_full_unstemmed | Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery |
| title_short | Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery |
| title_sort | recent advances in lipid protein conjugate based delivery systems in nutraceutical drug and gene delivery |
| topic | Lipid-protein conjugation Drug delivery Gene delivery Nutraceutical delivery Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S2667025922000024 |
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