Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction
Abstract Background Myocardial infarction (MI) elicits an intense acute inflammatory response that is essential for cardiac repair. However, an excessive inflammatory response also favors myocardial apoptosis, cardiac remodeling, and cardiovascular mortality. Omega-3 polyunsaturated fatty acids (ω-3...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Nutrition Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12937-019-0455-1 |
| _version_ | 1819104384551747584 |
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| author | Alessandra M. Campos-Staffico Ana Paula R. Costa Luiz Sérgio F. Carvalho Filipe A. Moura Simone N. Santos Otavio R. Coelho-Filho Wilson Nadruz José C. Quinaglia e Silva Andrei C. Sposito on behalf of Brasilia Heart Study |
| author_facet | Alessandra M. Campos-Staffico Ana Paula R. Costa Luiz Sérgio F. Carvalho Filipe A. Moura Simone N. Santos Otavio R. Coelho-Filho Wilson Nadruz José C. Quinaglia e Silva Andrei C. Sposito on behalf of Brasilia Heart Study |
| author_sort | Alessandra M. Campos-Staffico |
| collection | DOAJ |
| description | Abstract Background Myocardial infarction (MI) elicits an intense acute inflammatory response that is essential for cardiac repair. However, an excessive inflammatory response also favors myocardial apoptosis, cardiac remodeling, and cardiovascular mortality. Omega-3 polyunsaturated fatty acids (ω-3) bear anti-inflammatory effects, which may mitigate the inflammatory response during MI. This study investigated whether ω-3 intake is associated with attenuation of the MI-related inflammatory response and cardiac remodeling. Methods ST-elevation MI (STEMI) patients (n = 421) underwent clinical, biochemical, nutritional, 3D echocardiogram, Cardiac Magnetic Resonance imaging (CMRi) at 30 days and 3D echocardiogram imaging at six months after the MI. Blood tests were performed at day one (D1) and day five (D5) of hospitalization. Changes in inflammatory markers (ΔD5-D1) were calculated. A validated food frequency questionnaire estimated the nutritional consumption and ω-3 intake in the last 3 months before admission. Results The intake of ω-3 below the median (< 1.7 g/day) was associated with a short-term increase in hs-C-reactive protein [OR:1.96(1.24–3.10); p = 0.004], Interleukin-2 [OR:2.46(1.20–5.04); p = 0.014], brain-type natriuretic peptide [OR:2.66(1.30–5.44); p = 0.007], left-ventricle end-diastolic volume [OR:5.12(1.11–23.52)]; p = 0.036] and decreases in left-ventricle ejection fraction [OR:2.86(1.47–6.88); p = 0.017] after adjustment for covariates. No differences were observed in the extension of infarcted mass obtained by CMRi. Conclusion These findings suggest that a reduced daily intake of ω-3 may intensify outcome-determining mechanisms after STEMI, such as acute inflammatory response and late left ventricular remodeling. Trial registration Clinical Trial Registry number and website: NCT02062554. |
| first_indexed | 2024-12-22T02:05:30Z |
| format | Article |
| id | doaj.art-56045e83471447d7aab1599f8f7c02f1 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-22T02:05:30Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-56045e83471447d7aab1599f8f7c02f12022-12-21T18:42:33ZengBMCNutrition Journal1475-28912019-05-011811810.1186/s12937-019-0455-1Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarctionAlessandra M. Campos-Staffico0Ana Paula R. Costa1Luiz Sérgio F. Carvalho2Filipe A. Moura3Simone N. Santos4Otavio R. Coelho-Filho5Wilson Nadruz6José C. Quinaglia e Silva7Andrei C. Sposito8on behalf of Brasilia Heart StudyCardiology Department, State University of Campinas (Unicamp)Medical School, University of Brasilia (UnB)Cardiology Department, State University of Campinas (Unicamp)Cardiology Department, State University of Campinas (Unicamp)Cardiology Department, State University of Campinas (Unicamp)Cardiology Department, State University of Campinas (Unicamp)Cardiology Department, State University of Campinas (Unicamp)Hospital de Base do Distrito FederalCardiology Department, State University of Campinas (Unicamp)Abstract Background Myocardial infarction (MI) elicits an intense acute inflammatory response that is essential for cardiac repair. However, an excessive inflammatory response also favors myocardial apoptosis, cardiac remodeling, and cardiovascular mortality. Omega-3 polyunsaturated fatty acids (ω-3) bear anti-inflammatory effects, which may mitigate the inflammatory response during MI. This study investigated whether ω-3 intake is associated with attenuation of the MI-related inflammatory response and cardiac remodeling. Methods ST-elevation MI (STEMI) patients (n = 421) underwent clinical, biochemical, nutritional, 3D echocardiogram, Cardiac Magnetic Resonance imaging (CMRi) at 30 days and 3D echocardiogram imaging at six months after the MI. Blood tests were performed at day one (D1) and day five (D5) of hospitalization. Changes in inflammatory markers (ΔD5-D1) were calculated. A validated food frequency questionnaire estimated the nutritional consumption and ω-3 intake in the last 3 months before admission. Results The intake of ω-3 below the median (< 1.7 g/day) was associated with a short-term increase in hs-C-reactive protein [OR:1.96(1.24–3.10); p = 0.004], Interleukin-2 [OR:2.46(1.20–5.04); p = 0.014], brain-type natriuretic peptide [OR:2.66(1.30–5.44); p = 0.007], left-ventricle end-diastolic volume [OR:5.12(1.11–23.52)]; p = 0.036] and decreases in left-ventricle ejection fraction [OR:2.86(1.47–6.88); p = 0.017] after adjustment for covariates. No differences were observed in the extension of infarcted mass obtained by CMRi. Conclusion These findings suggest that a reduced daily intake of ω-3 may intensify outcome-determining mechanisms after STEMI, such as acute inflammatory response and late left ventricular remodeling. Trial registration Clinical Trial Registry number and website: NCT02062554.http://link.springer.com/article/10.1186/s12937-019-0455-1Omega-3Inflammatory responseCardiac remodelingSTEMI |
| spellingShingle | Alessandra M. Campos-Staffico Ana Paula R. Costa Luiz Sérgio F. Carvalho Filipe A. Moura Simone N. Santos Otavio R. Coelho-Filho Wilson Nadruz José C. Quinaglia e Silva Andrei C. Sposito on behalf of Brasilia Heart Study Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction Nutrition Journal Omega-3 Inflammatory response Cardiac remodeling STEMI |
| title | Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| title_full | Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| title_fullStr | Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| title_full_unstemmed | Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| title_short | Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| title_sort | omega 3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction |
| topic | Omega-3 Inflammatory response Cardiac remodeling STEMI |
| url | http://link.springer.com/article/10.1186/s12937-019-0455-1 |
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