Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost

Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost

The efficacy of COVID-19 vaccines appears to depend in complex ways on the vaccine dosage and the interval between the prime and boost doses. Unexpectedly, lower dose prime and longer prime-boost intervals have yielded higher efficacies in clinical trials. To elucidate the origins of these effects,...

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Bibliographic Details
Main Authors: Amar K. Garg, Soumya Mittal, Pranesh Padmanabhan, Rajat Desikan, Narendra M. Dixit
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
vaccine efficacy
affinity maturation
prime-boost immunization
germinal center (GC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.776933/full

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