Activated protein C in epilepsy pathophysiology
Epilepsy is one of the most common neurologic disorders that is characterized by recurrent seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy’s mechanism of development is not fully understood yet, but some of the common features of the disease are blood-brai...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1251017/full |
| _version_ | 1797660708665556992 |
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| author | Linda Ines Zoungrana Steven Didik Hao Wang Lily Slotabec Ji Li |
| author_facet | Linda Ines Zoungrana Steven Didik Hao Wang Lily Slotabec Ji Li |
| author_sort | Linda Ines Zoungrana |
| collection | DOAJ |
| description | Epilepsy is one of the most common neurologic disorders that is characterized by recurrent seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy’s mechanism of development is not fully understood yet, but some of the common features of the disease are blood-brain barrier disruption, microglia activation, and neuroinflammation. Those are also targets of activated protein C (APC). In fact, by downregulating thrombin, known as a pro-inflammatory, APC acts as an anti-inflammatory. APC is also an anti-apoptotic protein, instance by blocking p53-mediated apoptosis. APC’s neuroprotective effect could prevent blood-brain barrier dysfunction by acting on endothelial cells. Furthermore, through the downregulation of proapoptotic, and proinflammatory genes, APC’s neuroprotection could reduce the effect or prevent epilepsy pathogenesis. APC’s activity acts on blood-brain barrier disruption, inflammation, and apoptosis and causes neurogenesis, all hallmarks that could potentially treat or prevent epilepsy. Here we review both Activated Protein C and epilepsy mechanism, function, and the possible association between them. |
| first_indexed | 2024-03-11T18:34:53Z |
| format | Article |
| id | doaj.art-56065128c75d49e2af734a4c6cb2bb2a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T18:34:53Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-56065128c75d49e2af734a4c6cb2bb2a2023-10-13T05:29:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-10-011710.3389/fnins.2023.12510171251017Activated protein C in epilepsy pathophysiologyLinda Ines Zoungrana0Steven Didik1Hao Wang2Lily Slotabec3Ji Li4Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, United StatesDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, United StatesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United StatesEpilepsy is one of the most common neurologic disorders that is characterized by recurrent seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy’s mechanism of development is not fully understood yet, but some of the common features of the disease are blood-brain barrier disruption, microglia activation, and neuroinflammation. Those are also targets of activated protein C (APC). In fact, by downregulating thrombin, known as a pro-inflammatory, APC acts as an anti-inflammatory. APC is also an anti-apoptotic protein, instance by blocking p53-mediated apoptosis. APC’s neuroprotective effect could prevent blood-brain barrier dysfunction by acting on endothelial cells. Furthermore, through the downregulation of proapoptotic, and proinflammatory genes, APC’s neuroprotection could reduce the effect or prevent epilepsy pathogenesis. APC’s activity acts on blood-brain barrier disruption, inflammation, and apoptosis and causes neurogenesis, all hallmarks that could potentially treat or prevent epilepsy. Here we review both Activated Protein C and epilepsy mechanism, function, and the possible association between them.https://www.frontiersin.org/articles/10.3389/fnins.2023.1251017/fullepilepsyactivated protein Cseizureneuroprotectionneurologic disorders |
| spellingShingle | Linda Ines Zoungrana Steven Didik Hao Wang Lily Slotabec Ji Li Activated protein C in epilepsy pathophysiology Frontiers in Neuroscience epilepsy activated protein C seizure neuroprotection neurologic disorders |
| title | Activated protein C in epilepsy pathophysiology |
| title_full | Activated protein C in epilepsy pathophysiology |
| title_fullStr | Activated protein C in epilepsy pathophysiology |
| title_full_unstemmed | Activated protein C in epilepsy pathophysiology |
| title_short | Activated protein C in epilepsy pathophysiology |
| title_sort | activated protein c in epilepsy pathophysiology |
| topic | epilepsy activated protein C seizure neuroprotection neurologic disorders |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1251017/full |
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