Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil)
Abstract Background This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2859-x |
| _version_ | 1818552746367778816 |
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| author | Samantha Assis de Aguiar Samires Avelino de Souza França Barbara Brasil Santana Mike Barbosa Santos Felipe Bonfim Freitas Glenda Ferreira Izaura Cayres-Vallinoto Marluísa O. G. Ishak Ricardo Ishak Antonio Carlos Rosário Vallinoto |
| author_facet | Samantha Assis de Aguiar Samires Avelino de Souza França Barbara Brasil Santana Mike Barbosa Santos Felipe Bonfim Freitas Glenda Ferreira Izaura Cayres-Vallinoto Marluísa O. G. Ishak Ricardo Ishak Antonio Carlos Rosário Vallinoto |
| author_sort | Samantha Assis de Aguiar |
| collection | DOAJ |
| description | Abstract Background This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data with the epidemiological characteristics of the study population. Methods A total of 1899 biological samples were evaluated. The samples were screened for the presence of anti-HTLV antibodies using an enzyme-linked immunosorbent assay (ELISA), and infection was confirmed using conventional polymerase chain reaction (PCR), real-time PCR and nucleotide sequencing. Results Eleven samples (0.58%) were seropositive for HTLV, but molecular analysis confirmed positivity in only two samples (0.11%). Nucleotide sequencing and phylogenetic analysis indicated that the two samples positive for HTLV-1 that were isolated in Chaves belonged to the Cosmopolitan subtype 1 (HTLV-1a) and Transcontinental subgroup (A). Conclusion Our results confirmed the presence of Cosmopolitan Transcontinental HTLV-1 in the Marajó Archipelago, Amazon region, and the majority of the population revealed a lack of knowledge about sexually transmitted infections, which increases the risk of dissemination of HTLV and other agents. |
| first_indexed | 2024-12-12T09:17:12Z |
| format | Article |
| id | doaj.art-56068b6bdbb4450491b97d598022faa9 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T09:17:12Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-56068b6bdbb4450491b97d598022faa92022-12-22T00:29:21ZengBMCBMC Infectious Diseases1471-23342017-12-0117111110.1186/s12879-017-2859-xHuman T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil)Samantha Assis de Aguiar0Samires Avelino de Souza França1Barbara Brasil Santana2Mike Barbosa Santos3Felipe Bonfim Freitas4Glenda Ferreira5Izaura Cayres-Vallinoto6Marluísa O. G. Ishak7Ricardo Ishak8Antonio Carlos Rosário Vallinoto9Federal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyFederal University of Pará, Institute of Biological Sciences, Laboratory of VirologyAbstract Background This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data with the epidemiological characteristics of the study population. Methods A total of 1899 biological samples were evaluated. The samples were screened for the presence of anti-HTLV antibodies using an enzyme-linked immunosorbent assay (ELISA), and infection was confirmed using conventional polymerase chain reaction (PCR), real-time PCR and nucleotide sequencing. Results Eleven samples (0.58%) were seropositive for HTLV, but molecular analysis confirmed positivity in only two samples (0.11%). Nucleotide sequencing and phylogenetic analysis indicated that the two samples positive for HTLV-1 that were isolated in Chaves belonged to the Cosmopolitan subtype 1 (HTLV-1a) and Transcontinental subgroup (A). Conclusion Our results confirmed the presence of Cosmopolitan Transcontinental HTLV-1 in the Marajó Archipelago, Amazon region, and the majority of the population revealed a lack of knowledge about sexually transmitted infections, which increases the risk of dissemination of HTLV and other agents.http://link.springer.com/article/10.1186/s12879-017-2859-xHTLV-1aAEpidemiologyMarajó Island |
| spellingShingle | Samantha Assis de Aguiar Samires Avelino de Souza França Barbara Brasil Santana Mike Barbosa Santos Felipe Bonfim Freitas Glenda Ferreira Izaura Cayres-Vallinoto Marluísa O. G. Ishak Ricardo Ishak Antonio Carlos Rosário Vallinoto Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) BMC Infectious Diseases HTLV-1aA Epidemiology Marajó Island |
| title | Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) |
| title_full | Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) |
| title_fullStr | Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) |
| title_full_unstemmed | Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) |
| title_short | Human T-lymphotropic virus 1aA circulation and risk factors for sexually transmitted infections in an Amazon geographic area with lowest human development index (Marajó Island, Northern Brazil) |
| title_sort | human t lymphotropic virus 1aa circulation and risk factors for sexually transmitted infections in an amazon geographic area with lowest human development index marajo island northern brazil |
| topic | HTLV-1aA Epidemiology Marajó Island |
| url | http://link.springer.com/article/10.1186/s12879-017-2859-x |
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