Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract
Background/Aim. All the functions of the digestive system are controlled, guided and initiated by the autonomic nervous system. A special part of this system placed in the wall of the gastrointestinal tract is known as the enteric or metasympathetic nervous system. The aim of this study was...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2016-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600046M.pdf |
| _version_ | 1818561605905940480 |
|---|---|
| author | Mandić Predrag Filipović Tatjana Gašić Miloš Đukić-Macut Nataša Filipović Milan Bogosavljević Ivan |
| author_facet | Mandić Predrag Filipović Tatjana Gašić Miloš Đukić-Macut Nataša Filipović Milan Bogosavljević Ivan |
| author_sort | Mandić Predrag |
| collection | DOAJ |
| description | Background/Aim. All the functions of the digestive system are controlled,
guided and initiated by the autonomic nervous system. A special part of this
system placed in the wall of the gastrointestinal tract is known as the
enteric or metasympathetic nervous system. The aim of this study was to
analyse myenteric nervous plexus in different parts of the digestive tract.
Methods. We examined the myenteric nervous plexus of the esophagus, stomach,
duodenum, jejunum, ileum, transverse colon and rectum in tissue samples taken
from 30 cadavers of persons aged 20-84 years. After standard histological
processing sections were stained with hematoxylineosin, cresyl violet (CV)
and AgNO3 method. Multipurpose test system M42 was used in morphometric
analysis. The results were analyzed by t-test and analysis of variance.
Results. The number of neurons per cm2 surface was the lowest in the
esophagus (2.045 ± 310.30) and the largest in the duodenum (65,511 ± 5,639).
The statistical processing showed significant differences (p < 0.001) in the
number of neurons between the esophagus and all other parts of the digestive
tract. The maximal value of the average surface of the myenteric nervous
plexus neurons was observed in the esophagus (588.93 ± 30.45 μm2) and the
lowest in the stomach (296.46 ± 22.53 μm2). Conclusion. There are differences
in the number of ganglion cells among different parts of the human digestive
tract. The differences range from a few to several tens of thousands of
neuron/cm2. The myenteric nervous plexus of the esophagus was characterized
by a significantly smaller number of neurons but their bodies and nuclei are
significantly larger compared to other parts of the digestive tract. |
| first_indexed | 2024-12-14T00:53:02Z |
| format | Article |
| id | doaj.art-56081a9db2ed40c9bab92530534b56c8 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-14T00:53:02Z |
| publishDate | 2016-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-56081a9db2ed40c9bab92530534b56c82022-12-21T23:23:44ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202016-01-0173655956510.2298/VSP141231046M0042-84501600046MQuantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tractMandić Predrag0Filipović Tatjana1Gašić Miloš2Đukić-Macut Nataša3Filipović Milan4Bogosavljević Ivan5Faculty of Medicine, Institute of Anatomy, Kosovska MitrovicaFaculty of Medicine, Institute of Anatomy, Kosovska MitrovicaFaculty of Medicine, Institute of Anatomy, Kosovska MitrovicaFaculty of Medicine, Institute of Anatomy, Kosovska MitrovicaFaculty of Medicine, Clinic of Surgery, Kosovska MitrovicaFaculty of Medicine, Institute of Anatomy, Kosovska MitrovicaBackground/Aim. All the functions of the digestive system are controlled, guided and initiated by the autonomic nervous system. A special part of this system placed in the wall of the gastrointestinal tract is known as the enteric or metasympathetic nervous system. The aim of this study was to analyse myenteric nervous plexus in different parts of the digestive tract. Methods. We examined the myenteric nervous plexus of the esophagus, stomach, duodenum, jejunum, ileum, transverse colon and rectum in tissue samples taken from 30 cadavers of persons aged 20-84 years. After standard histological processing sections were stained with hematoxylineosin, cresyl violet (CV) and AgNO3 method. Multipurpose test system M42 was used in morphometric analysis. The results were analyzed by t-test and analysis of variance. Results. The number of neurons per cm2 surface was the lowest in the esophagus (2.045 ± 310.30) and the largest in the duodenum (65,511 ± 5,639). The statistical processing showed significant differences (p < 0.001) in the number of neurons between the esophagus and all other parts of the digestive tract. The maximal value of the average surface of the myenteric nervous plexus neurons was observed in the esophagus (588.93 ± 30.45 μm2) and the lowest in the stomach (296.46 ± 22.53 μm2). Conclusion. There are differences in the number of ganglion cells among different parts of the human digestive tract. The differences range from a few to several tens of thousands of neuron/cm2. The myenteric nervous plexus of the esophagus was characterized by a significantly smaller number of neurons but their bodies and nuclei are significantly larger compared to other parts of the digestive tract.http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600046M.pdfdigestive systemmyenteric plexusneuronscell counthistological techniquescadaver |
| spellingShingle | Mandić Predrag Filipović Tatjana Gašić Miloš Đukić-Macut Nataša Filipović Milan Bogosavljević Ivan Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract Vojnosanitetski Pregled digestive system myenteric plexus neurons cell count histological techniques cadaver |
| title | Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| title_full | Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| title_fullStr | Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| title_full_unstemmed | Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| title_short | Quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| title_sort | quantitative morphometric analysis of the myenteric nervous plexus ganglion structures along the human digestive tract |
| topic | digestive system myenteric plexus neurons cell count histological techniques cadaver |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600046M.pdf |
| work_keys_str_mv | AT mandicpredrag quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract AT filipovictatjana quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract AT gasicmilos quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract AT đukicmacutnatasa quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract AT filipovicmilan quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract AT bogosavljevicivan quantitativemorphometricanalysisofthemyentericnervousplexusganglionstructuresalongthehumandigestivetract |