Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation

Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation

Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages of cross-species disease modeling, animal models of...

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Bibliographic Details
Main Authors: Maryline Abrial, Sandeep Basu, Mengmeng Huang, Vincent Butty, Asya Schwertner, Spencer Jeffrey, Daniel Jordan, Caroline E. Burns, C. Geoffrey Burns
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Disease Models & Mechanisms
Subjects:
zebrafish
outflow tract
thoracic aortic aneurysm
ltbp proteins
tgfβ signaling
Online Access:http://dmm.biologists.org/content/15/3/dmm046979

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