Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)
Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Background: Quantitative assessment of CBFGM may provide a...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921000185 |
| _version_ | 1818416199659159552 |
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| author | Caoilfhionn Ní Leidhin Jason McMorrow Daniel Carey Louise Newman Wilby Williamson Andrew J. Fagan Michael A. Chappell Rose Anne Kenny James F. Meaney Silvin P. Knight |
| author_facet | Caoilfhionn Ní Leidhin Jason McMorrow Daniel Carey Louise Newman Wilby Williamson Andrew J. Fagan Michael A. Chappell Rose Anne Kenny James F. Meaney Silvin P. Knight |
| author_sort | Caoilfhionn Ní Leidhin |
| collection | DOAJ |
| description | Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Background: Quantitative assessment of CBFGM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBFGM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion. Methods: The study cohort comprised a subset of wave 3 (2014–2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBFGM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations. Results: The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBFGM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBFGM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = −0.3, −0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001). Conclusions: This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBFGM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBFGM. |
| first_indexed | 2024-12-14T11:47:06Z |
| format | Article |
| id | doaj.art-560a05057ded40d1a480ea27d9a13c16 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-14T11:47:06Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-560a05057ded40d1a480ea27d9a13c162022-12-21T23:02:33ZengElsevierNeuroImage1095-95722021-04-01229117741Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)Caoilfhionn Ní Leidhin0Jason McMorrow1Daniel Carey2Louise Newman3Wilby Williamson4Andrew J. Fagan5Michael A. Chappell6Rose Anne Kenny7James F. Meaney8Silvin P. Knight9School of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, IrelandDepartment of Radiology, Mayo Clinic, Rochester, MN, USARadiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Sir Peter Mansfield Imaging Center, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Nottingham Biomedical Research Centre, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomSchool of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland; The Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland; Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, IrelandSchool of Medicine, Trinity College Dublin, Ireland; The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Ireland; Corresponding author at: The Irish Longitudinal Study on Ageing (TILDA), Trinity Central, 152-160 Pearse St, Dublin 2 D02 R590, Republic of Ireland.Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Background: Quantitative assessment of CBFGM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBFGM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion. Methods: The study cohort comprised a subset of wave 3 (2014–2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBFGM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations. Results: The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBFGM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBFGM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = −0.3, −0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001). Conclusions: This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBFGM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBFGM.http://www.sciencedirect.com/science/article/pii/S1053811921000185Cerebral blood flowCerebral perfusionArterial spin labelling magnetic resonance imagingASL MRIAgeingNormative values |
| spellingShingle | Caoilfhionn Ní Leidhin Jason McMorrow Daniel Carey Louise Newman Wilby Williamson Andrew J. Fagan Michael A. Chappell Rose Anne Kenny James F. Meaney Silvin P. Knight Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) NeuroImage Cerebral blood flow Cerebral perfusion Arterial spin labelling magnetic resonance imaging ASL MRI Ageing Normative values |
| title | Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) |
| title_full | Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) |
| title_fullStr | Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) |
| title_full_unstemmed | Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) |
| title_short | Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA) |
| title_sort | age related normative changes in cerebral perfusion data from the irish longitudinal study on ageing tilda |
| topic | Cerebral blood flow Cerebral perfusion Arterial spin labelling magnetic resonance imaging ASL MRI Ageing Normative values |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921000185 |
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