Clinical Utility of Fecal Immunochemical Transferrin Test in Gastrointestinal Bleeding Detection
Background: Gastrointestinal (GI) bleeding can result from various conditions, including ulcers, neoplasms and infectious enterocolitis. The aim of this study was to evaluate the utility of the fecal immunochemical transferrin test compared with the fecal Hb test in various clinical settings.Methods...
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| Format: | Article |
| Language: | English |
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Korean Society of Clinical Microbiology
2018-09-01
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| Series: | Annals of Clinical Microbiology |
| Subjects: | |
| Online Access: | https://www.acm.or.kr/article_aws/?num=KJCM2018_51 |
| _version_ | 1818232564185300992 |
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| author | Jong-Mi Lee Mi Jung Park Woong Heo Kang Gyun Park Yong Gyu Park Seung Beom Han Young-Seok Cho Yeon-Joon Park |
| author_facet | Jong-Mi Lee Mi Jung Park Woong Heo Kang Gyun Park Yong Gyu Park Seung Beom Han Young-Seok Cho Yeon-Joon Park |
| author_sort | Jong-Mi Lee |
| collection | DOAJ |
| description | Background: Gastrointestinal (GI) bleeding can result
from various conditions, including ulcers, neoplasms
and infectious enterocolitis. The aim of this study
was to evaluate the utility of the fecal immunochemical
transferrin test compared with the fecal Hb test
in various clinical settings.Methods: A total of 1,116 clinical stool specimens
submitted for fecal occult blood testing were prospectively
examined using both FIT Hb and FIT Tf
kits (AlfresaPharma, Japan). To verify the specificity
of the two tests, stool specimens from 265 health
check-up examinees were also included.Results: A review of medical records revealed that
396 patients had clinical conditions associated with
GI bleeding. FIT Hb and FIT Tf results were positive
in 156 (39.4%) and 137 (34.6%) cases, respectively,
and an additional 194 (49.0%) cases tested positive
with either FIT Hb or FIT Tf. The two tests showed a
moderate strength of agreement (kappa value; 0.56).
Colitis (n=71) was associated with the most GI bleedings,
followed by acute gastroenteritis (n=29), GI ulcers
(n=27) and GI cancers (n=15). While the first
two groups had higher positive rates on FIT Tf, patients
in the latter two groups had higher positive
rates on FIT Hb. Notably, four of nine specimens
from premature babies tested positive only on FIT Tf.
The specificity of FIT Hb and FIT Tf was 100% and
99.6%, respectively.Conclusion: Concurrent use of FIT Hb and FIT Tf improved
the detection rate of occult GI bleeding, especially
in patients with infectious GI disease (such as
colitis or gastroenteritis) and in premature babies.
(Ann Clin Microbiol 2018;21:51-57) |
| first_indexed | 2024-12-12T11:08:17Z |
| format | Article |
| id | doaj.art-560c22437ba040b6bb7ac6e9b31a8535 |
| institution | Directory Open Access Journal |
| issn | 2288-0585 2288-6850 |
| language | English |
| last_indexed | 2024-12-12T11:08:17Z |
| publishDate | 2018-09-01 |
| publisher | Korean Society of Clinical Microbiology |
| record_format | Article |
| series | Annals of Clinical Microbiology |
| spelling | doaj.art-560c22437ba040b6bb7ac6e9b31a85352022-12-22T00:26:21ZengKorean Society of Clinical MicrobiologyAnnals of Clinical Microbiology2288-05852288-68502018-09-01213475010.5145/ACM.2018.21.3.51KJCM2018_51Clinical Utility of Fecal Immunochemical Transferrin Test in Gastrointestinal Bleeding DetectionJong-Mi Lee0Mi Jung Park1Woong Heo2Kang Gyun Park3Yong Gyu Park4Seung Beom Han5Young-Seok Cho6Yeon-Joon Park7 Departments of Laboratory Medicine Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Departments of Laboratory Medicine Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Departments of Laboratory Medicine Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Departments of Laboratory Medicine Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Medical Life Science Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Pediatrics Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Gastroenterology Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Departments of Laboratory Medicine Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul Background: Gastrointestinal (GI) bleeding can result from various conditions, including ulcers, neoplasms and infectious enterocolitis. The aim of this study was to evaluate the utility of the fecal immunochemical transferrin test compared with the fecal Hb test in various clinical settings.Methods: A total of 1,116 clinical stool specimens submitted for fecal occult blood testing were prospectively examined using both FIT Hb and FIT Tf kits (AlfresaPharma, Japan). To verify the specificity of the two tests, stool specimens from 265 health check-up examinees were also included.Results: A review of medical records revealed that 396 patients had clinical conditions associated with GI bleeding. FIT Hb and FIT Tf results were positive in 156 (39.4%) and 137 (34.6%) cases, respectively, and an additional 194 (49.0%) cases tested positive with either FIT Hb or FIT Tf. The two tests showed a moderate strength of agreement (kappa value; 0.56). Colitis (n=71) was associated with the most GI bleedings, followed by acute gastroenteritis (n=29), GI ulcers (n=27) and GI cancers (n=15). While the first two groups had higher positive rates on FIT Tf, patients in the latter two groups had higher positive rates on FIT Hb. Notably, four of nine specimens from premature babies tested positive only on FIT Tf. The specificity of FIT Hb and FIT Tf was 100% and 99.6%, respectively.Conclusion: Concurrent use of FIT Hb and FIT Tf improved the detection rate of occult GI bleeding, especially in patients with infectious GI disease (such as colitis or gastroenteritis) and in premature babies. (Ann Clin Microbiol 2018;21:51-57)https://www.acm.or.kr/article_aws/?num=KJCM2018_51fecal occult blood testhemoglobinprematuritytransferrin |
| spellingShingle | Jong-Mi Lee Mi Jung Park Woong Heo Kang Gyun Park Yong Gyu Park Seung Beom Han Young-Seok Cho Yeon-Joon Park Clinical Utility of Fecal Immunochemical Transferrin Test in Gastrointestinal Bleeding Detection Annals of Clinical Microbiology fecal occult blood test hemoglobin prematurity transferrin |
| title | Clinical Utility of Fecal Immunochemical Transferrin Test in
Gastrointestinal Bleeding Detection |
| title_full | Clinical Utility of Fecal Immunochemical Transferrin Test in
Gastrointestinal Bleeding Detection |
| title_fullStr | Clinical Utility of Fecal Immunochemical Transferrin Test in
Gastrointestinal Bleeding Detection |
| title_full_unstemmed | Clinical Utility of Fecal Immunochemical Transferrin Test in
Gastrointestinal Bleeding Detection |
| title_short | Clinical Utility of Fecal Immunochemical Transferrin Test in
Gastrointestinal Bleeding Detection |
| title_sort | clinical utility of fecal immunochemical transferrin test in gastrointestinal bleeding detection |
| topic | fecal occult blood test hemoglobin prematurity transferrin |
| url | https://www.acm.or.kr/article_aws/?num=KJCM2018_51 |
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