Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis
Objective: This study was intended to provide data to support the effect of Shashen Maidong Decoction in improving mycoplasma pneumonia in pediatric patients through systematic evaluation.Methods: PubMed, the Web of Science, EMbase, CNKI, CQVIP, Wan-Fang, and CBM databases were comprehensively searc...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.765656/full |
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| author | Jiawei Wang Jiawei Wang Xiao Ma Shizhang Wei Shizhang Wei Tao Yang Tao Yang Yuling Tong Yuling Tong Manyi Jing Jianxia Wen Jianxia Wen Yanling Zhao |
| author_facet | Jiawei Wang Jiawei Wang Xiao Ma Shizhang Wei Shizhang Wei Tao Yang Tao Yang Yuling Tong Yuling Tong Manyi Jing Jianxia Wen Jianxia Wen Yanling Zhao |
| author_sort | Jiawei Wang |
| collection | DOAJ |
| description | Objective: This study was intended to provide data to support the effect of Shashen Maidong Decoction in improving mycoplasma pneumonia in pediatric patients through systematic evaluation.Methods: PubMed, the Web of Science, EMbase, CNKI, CQVIP, Wan-Fang, and CBM databases were comprehensively searched from established in June 2021. Randomized controlled trials of TRQI were selected by screening the literature and extracting information. The Cochrane RCT Evaluation Manual was used to evaluate the methodological quality of all included studies, and Meta-analysis was performed using Stata 14.0 and Review Manager 5.4 software.Results: A total of 1,127 patients from 12 clinical studies met the inclusion criteria. Meta-analysis results showed that the treatment group of Shashen Maidong Decoction was able to significantly increase the overall efficiency level and significantly reduce the incidence of adverse reactions, time for disappearance of cough, time for relief of cough, time for defervescence, time for disappearance of lung rales, time for return to normal of chest X-ray, T lymphocyte subpopulation (CD3+) and tumor necrosis factor-α (TNF-α) and other index levels (p < 0.05).Conclusion: Shashen Maidong Decoction has a significant improvement in the levels of relevant indexes in pediatric mycoplasma pneumonia, which provides a basis for the safety and efficacy of pediatric mycoplasma pneumonia. However, due to the small sample size included in the study, the study quality was not high, and more randomized controlled trials of high quality are required for further validation. |
| first_indexed | 2024-12-13T21:52:55Z |
| format | Article |
| id | doaj.art-560d42e2bba8485db27c582db43b1e92 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T21:52:55Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-560d42e2bba8485db27c582db43b1e922022-12-21T23:30:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.765656765656Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-AnalysisJiawei Wang0Jiawei Wang1Xiao Ma2Shizhang Wei3Shizhang Wei4Tao Yang5Tao Yang6Yuling Tong7Yuling Tong8Manyi Jing9Jianxia Wen10Jianxia Wen11Yanling Zhao12Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaObjective: This study was intended to provide data to support the effect of Shashen Maidong Decoction in improving mycoplasma pneumonia in pediatric patients through systematic evaluation.Methods: PubMed, the Web of Science, EMbase, CNKI, CQVIP, Wan-Fang, and CBM databases were comprehensively searched from established in June 2021. Randomized controlled trials of TRQI were selected by screening the literature and extracting information. The Cochrane RCT Evaluation Manual was used to evaluate the methodological quality of all included studies, and Meta-analysis was performed using Stata 14.0 and Review Manager 5.4 software.Results: A total of 1,127 patients from 12 clinical studies met the inclusion criteria. Meta-analysis results showed that the treatment group of Shashen Maidong Decoction was able to significantly increase the overall efficiency level and significantly reduce the incidence of adverse reactions, time for disappearance of cough, time for relief of cough, time for defervescence, time for disappearance of lung rales, time for return to normal of chest X-ray, T lymphocyte subpopulation (CD3+) and tumor necrosis factor-α (TNF-α) and other index levels (p < 0.05).Conclusion: Shashen Maidong Decoction has a significant improvement in the levels of relevant indexes in pediatric mycoplasma pneumonia, which provides a basis for the safety and efficacy of pediatric mycoplasma pneumonia. However, due to the small sample size included in the study, the study quality was not high, and more randomized controlled trials of high quality are required for further validation.https://www.frontiersin.org/articles/10.3389/fphar.2021.765656/fullshashen maidong decoctionpediatric mycoplasma pneumoniasystematic reviewmeta-analysisclinical research |
| spellingShingle | Jiawei Wang Jiawei Wang Xiao Ma Shizhang Wei Shizhang Wei Tao Yang Tao Yang Yuling Tong Yuling Tong Manyi Jing Jianxia Wen Jianxia Wen Yanling Zhao Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis Frontiers in Pharmacology shashen maidong decoction pediatric mycoplasma pneumonia systematic review meta-analysis clinical research |
| title | Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis |
| title_full | Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis |
| title_fullStr | Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis |
| title_short | Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis |
| title_sort | clinical efficacy and safety of shashen maidong decoction in the treatment of pediatric mycoplasma pneumonia a systematic review and meta analysis |
| topic | shashen maidong decoction pediatric mycoplasma pneumonia systematic review meta-analysis clinical research |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.765656/full |
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