Adult influenza epidemic is associated with out-of-hospital cardiac arrest

Adult influenza epidemic is associated with out-of-hospital cardiac arrest

Abstract. It has been reported that influenza infection is associated with out-of-hospital cardiac arrest of cardiac origin (OHCA-CA). However, the association between OHCA-CA and influenza epidemics in adults has not been well investigated. We analyzed data from the All-Japan Utstein Registry, a pr...

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Main Authors: Yasunori Suematsu, MD, PhD, Takashi Kuwano, MD, PhD, Motoki Yamashita, MD, PhD, Hiroyuki Tsutsui, MD, PhD, Naoki Sato, MD, PhD, Takanori Ikeda, MD, PhD, Ken Nagao, MD, PhD, Naohiro Yonemoto, MPH, PhD, Yoshio Tahara, MD, PhD, Keijiro Saku, MD, PhD, Shin-ichiro Miura, MD, PhD, on behalf of the Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Group
Format: Article
Language:English
Published: Wolters Kluwer 2022-06-01
Series:Medicine
Online Access:http://journals.lww.com/10.1097/MD.0000000000029535
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Summary:Abstract. It has been reported that influenza infection is associated with out-of-hospital cardiac arrest of cardiac origin (OHCA-CA). However, the association between OHCA-CA and influenza epidemics in adults has not been well investigated. We analyzed data from the All-Japan Utstein Registry, a prospective, nationwide, population-based, observational study, regarding OHCA-CA cases and the Infectious Diseases Weekly Report for influenza cases: 17,710 OHCA-CA cases and 764,808 influenza cases were recorded between 2005 and 2015 in Fukuoka, Japan. The weekly average number of OHCA-CA cases was positively associated with the number of patients with influenza infection (r = 0.70, P < .0001). To eliminate the effects of season and age, we investigated only adults in winter. The weekly number of OHCA-CA cases was positively associated with the number of patients with influenza infection in weeks when there was a high frequency of influenza infection in adults (r = 0.36, P = .006), but not in weeks with a medium (r = 0.26, P = .05) or low frequency of influenza infection (r = 0.003, P = 1.0). In weeks during which there was a high frequency of influenza infection, the weekly number of OHCA-CA cases was positively associated with the number of influenza infections in males (r = 0.37, P = .006), but not females (r = 0.18, P = .2). The number of OHCA-CA cases was positively associated with the number of influenza infections in adult males during weeks in which there was a high frequency of influenza infections. To help prevent OHCA-CA in males, it might be beneficial to announce influenza epidemics specifically in adults, in addition to all ages.
ISSN:0025-7974
1536-5964

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