Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis [version 2; peer review: 1 approved, 2 approved with reservations]

Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis [version 2; peer review: 1 approved, 2 approved with reservations]

Background. Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinamide were investigated in hospitalized TB/HIV patients and a cohort of outpatients with TB (with or without HIV) to deter...

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Bibliographic Details
Main Authors: Helen McIlleron, Lubbe Wiesner, Charlotte Schutz, Robert J. Wilkinson, Graeme Meintjes, Noha Abdelgawad, David Barr, Maxwell Chirehwa, Saskia Janssen, Amy Ward, Muki Shey, Rosie Burton, Gary Maartens, Paolo Denti
Format: Article
Language:English
Published: Wellcome 2022-11-01
Series:Wellcome Open Research
Subjects:
rifampicin
isoniazid
pyrazinamide
hospitalization
tuberculosis
eng
Online Access:https://wellcomeopenresearch.org/articles/7-72/v2

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