Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material
Abstract Objective Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In the present study, the physical and biological properties of nanoporous stainless steel as well as its usefulness for drug deli...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2021-09-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-021-00232-8 |
| _version_ | 1797283031713579008 |
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| author | Inho Bae Kyung-Seob Lim Jun-Kyu Park Ju Han Song Sin-Hye Oh Jung-Woo Kim Zijiao Zhang Chan Park Jeong-Tae Koh |
| author_facet | Inho Bae Kyung-Seob Lim Jun-Kyu Park Ju Han Song Sin-Hye Oh Jung-Woo Kim Zijiao Zhang Chan Park Jeong-Tae Koh |
| author_sort | Inho Bae |
| collection | DOAJ |
| description | Abstract Objective Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In the present study, the physical and biological properties of nanoporous stainless steel as well as its usefulness for drug delivery were assessed. Methods The specimen was prepared with a circular disk shape (15 mm in diameter and 1 mm in thickness). The disk was subjected to electropolishing at a constant voltage of 20 V and 10 A for 10 min in an acidic environment (50% H2SO4). Everolimus (EVL) was used as a testing drug for drug-loading capacity of the material surface and release kinetics. The physiobiological properties of the material were assessed using platelet adhesion, and smooth muscle cell (SMC) adhesion, migration, and proliferation assays. Results The surface roughness of the postpolishing group was greater than that of the nonpolishing group. Platelet adhesion and SMC adhesion and migration were inhibited in the postpolishing group compared to those in the prepolishing group. In the postpolishing group, the total amount of EVL on the surface (i.e., drug storage rate) was higher and the drug release rate was lower, with half the amount of the EVL released within 4 days compared with only 1 day for that of the prepolishing group. Conclusion Taken together, this stainless steel with a nanoporous surface could be used as a medical device for controlling cellular responses and carrying drugs. |
| first_indexed | 2024-03-07T17:23:00Z |
| format | Article |
| id | doaj.art-5611bd066df243498e376d56eb08c66b |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T17:23:00Z |
| publishDate | 2021-09-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-5611bd066df243498e376d56eb08c66b2024-03-02T19:32:43ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242021-09-012511810.1186/s40824-021-00232-8Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel materialInho Bae0Kyung-Seob Lim1Jun-Kyu Park2Ju Han Song3Sin-Hye Oh4Jung-Woo Kim5Zijiao Zhang6Chan Park7Jeong-Tae Koh8Hard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityNational Primate Research Center & Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Polymer Science and Engineering, Sunchon National UniversityHard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityHard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityHard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityHard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityDepartment of Prosthodontics, School of Dentistry, Chonnam National UniversityHard-tissue Biointerface Research Center; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National UniversityAbstract Objective Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In the present study, the physical and biological properties of nanoporous stainless steel as well as its usefulness for drug delivery were assessed. Methods The specimen was prepared with a circular disk shape (15 mm in diameter and 1 mm in thickness). The disk was subjected to electropolishing at a constant voltage of 20 V and 10 A for 10 min in an acidic environment (50% H2SO4). Everolimus (EVL) was used as a testing drug for drug-loading capacity of the material surface and release kinetics. The physiobiological properties of the material were assessed using platelet adhesion, and smooth muscle cell (SMC) adhesion, migration, and proliferation assays. Results The surface roughness of the postpolishing group was greater than that of the nonpolishing group. Platelet adhesion and SMC adhesion and migration were inhibited in the postpolishing group compared to those in the prepolishing group. In the postpolishing group, the total amount of EVL on the surface (i.e., drug storage rate) was higher and the drug release rate was lower, with half the amount of the EVL released within 4 days compared with only 1 day for that of the prepolishing group. Conclusion Taken together, this stainless steel with a nanoporous surface could be used as a medical device for controlling cellular responses and carrying drugs.https://doi.org/10.1186/s40824-021-00232-8Nanoporous structureStainless steelSurface modificationCellular responseDrug delivery |
| spellingShingle | Inho Bae Kyung-Seob Lim Jun-Kyu Park Ju Han Song Sin-Hye Oh Jung-Woo Kim Zijiao Zhang Chan Park Jeong-Tae Koh Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material Biomaterials Research Nanoporous structure Stainless steel Surface modification Cellular response Drug delivery |
| title | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| title_full | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| title_fullStr | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| title_full_unstemmed | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| title_short | Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| title_sort | evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material |
| topic | Nanoporous structure Stainless steel Surface modification Cellular response Drug delivery |
| url | https://doi.org/10.1186/s40824-021-00232-8 |
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