Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity
Childhood adversity is heterogeneous with potentially distinct dimensions of violence exposure and social deprivation. These dimensions may differentially shape emotion-based neural circuitry, such as amygdala–PFC white matter connectivity. Amygdala–orbitofrontal cortex (OFC) white matter connectivi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929320300992 |
| _version_ | 1818498636883951616 |
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| author | Leigh G. Goetschius Tyler C. Hein Colter Mitchell Nestor L. Lopez-Duran Vonnie C. McLoyd Jeanne Brooks-Gunn Sara S. McLanahan Luke W. Hyde Christopher S. Monk |
| author_facet | Leigh G. Goetschius Tyler C. Hein Colter Mitchell Nestor L. Lopez-Duran Vonnie C. McLoyd Jeanne Brooks-Gunn Sara S. McLanahan Luke W. Hyde Christopher S. Monk |
| author_sort | Leigh G. Goetschius |
| collection | DOAJ |
| description | Childhood adversity is heterogeneous with potentially distinct dimensions of violence exposure and social deprivation. These dimensions may differentially shape emotion-based neural circuitry, such as amygdala–PFC white matter connectivity. Amygdala–orbitofrontal cortex (OFC) white matter connectivity has been linked to regulation of the amygdala’s response to emotional stimuli. Using a preregistered analysis plan, we prospectively examined the effects of childhood exposure to two dimensions of adversity, violence exposure and social deprivation, on the adolescent amygdala–PFC white matter connectivity. We also reproduced the negative correlation between amygdala–PFC white matter connectivity and amygdala activation to threat faces. 183 15−17-year-olds were recruited from the Fragile Families and Child Wellbeing Study — a longitudinal, birth cohort, sample of predominantly low-income youth. Probabilistic tractography revealed that childhood violence exposure and social deprivation interacted to predict the probability of adolescent right hemisphere amygdala–OFC white matter connectivity. High violence exposure with high social deprivation related to less amygdala–OFC white matter connectivity. Violence exposure was not associated with white matter connectivity when social deprivation was at mean or low levels (i.e., relatively socially supportive contexts). Therefore, social deprivation may exacerbate the effects of childhood violence exposure on the development of white matter connections involved in emotion processing and regulation. Conversely, social support may buffer against them. |
| first_indexed | 2024-12-10T20:18:17Z |
| format | Article |
| id | doaj.art-56125f8dbd814dd1943f01cf7cd03d8b |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-10T20:18:17Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-56125f8dbd814dd1943f01cf7cd03d8b2022-12-22T01:35:08ZengElsevierDevelopmental Cognitive Neuroscience1878-92932020-10-0145100849Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivityLeigh G. Goetschius0Tyler C. Hein1Colter Mitchell2Nestor L. Lopez-Duran3Vonnie C. McLoyd4Jeanne Brooks-Gunn5Sara S. McLanahan6Luke W. Hyde7Christopher S. Monk8Department of Psychology, University of Michigan, Ann Arbor, MI, 48109, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109, United States; Serious Mental Illness Treatment Resource and Evaluation Center (SMITREC), Office of Mental Health and Suicide Prevention, Department of Veterans Affairs, United StatesSurvey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, 48109, United States; Population Studies Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, 48109, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109, United StatesTeachers College & College of Physicians and Surgeons, Columbia University, 10027, United StatesDepartment of Sociology, Princeton University, 08544, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109, United States; Survey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, 48109, United States; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, 48109, United States; Survey Research Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, 48109, United States; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, United States; Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, United States; Corresponding author at: 2000 East Hall, 530 Church St, University of Michigan, Ann Arbor, MI 48109-1043, United States.Childhood adversity is heterogeneous with potentially distinct dimensions of violence exposure and social deprivation. These dimensions may differentially shape emotion-based neural circuitry, such as amygdala–PFC white matter connectivity. Amygdala–orbitofrontal cortex (OFC) white matter connectivity has been linked to regulation of the amygdala’s response to emotional stimuli. Using a preregistered analysis plan, we prospectively examined the effects of childhood exposure to two dimensions of adversity, violence exposure and social deprivation, on the adolescent amygdala–PFC white matter connectivity. We also reproduced the negative correlation between amygdala–PFC white matter connectivity and amygdala activation to threat faces. 183 15−17-year-olds were recruited from the Fragile Families and Child Wellbeing Study — a longitudinal, birth cohort, sample of predominantly low-income youth. Probabilistic tractography revealed that childhood violence exposure and social deprivation interacted to predict the probability of adolescent right hemisphere amygdala–OFC white matter connectivity. High violence exposure with high social deprivation related to less amygdala–OFC white matter connectivity. Violence exposure was not associated with white matter connectivity when social deprivation was at mean or low levels (i.e., relatively socially supportive contexts). Therefore, social deprivation may exacerbate the effects of childhood violence exposure on the development of white matter connections involved in emotion processing and regulation. Conversely, social support may buffer against them.http://www.sciencedirect.com/science/article/pii/S1878929320300992Diffusion MRIEarly adversityEmotion processingAmygdalaOFCLongitudinal |
| spellingShingle | Leigh G. Goetschius Tyler C. Hein Colter Mitchell Nestor L. Lopez-Duran Vonnie C. McLoyd Jeanne Brooks-Gunn Sara S. McLanahan Luke W. Hyde Christopher S. Monk Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity Developmental Cognitive Neuroscience Diffusion MRI Early adversity Emotion processing Amygdala OFC Longitudinal |
| title | Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity |
| title_full | Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity |
| title_fullStr | Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity |
| title_full_unstemmed | Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity |
| title_short | Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity |
| title_sort | childhood violence exposure and social deprivation predict adolescent amygdala orbitofrontal cortex white matter connectivity |
| topic | Diffusion MRI Early adversity Emotion processing Amygdala OFC Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S1878929320300992 |
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