Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients
Objective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients. Study Design: This was a case control study. Place and Duration of Study: The study was conducted in biochemistry department of Islamic International Medical Colle...
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| Format: | Article |
| Language: | English |
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Riphah International University, Islamabad
2021-11-01
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| Series: | Journal of Islamic International Medical College |
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| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1044 |
| Summary: | Objective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients.
Study Design: This was a case control study.
Place and Duration of Study: The study was conducted in biochemistry department of Islamic International Medical College- Trust (IIMC-T) Rawalpindi from 15 March 2016 to 14 March 2017.
Materials and Methods: The study included 160 subjects divided into two groups Aphthous group and Non- Aphthous group. Aphthous group comprised of 70 recurrent aphthous stomatitis patients with active lesion and 90 age and sex matched healthy controls were included in the non-aphthous group .From all the participants 2 ml of blood was taken. Serum glutathione peroxidase levels were measured using enzyme linked immunosorbent assay technique. This ELISA kit uses Sandwich-ELISA as the method.
Results: The comparison of mean of serum glutathione peroxidase levels between aphthous and non-aphthous group was significant (p<o.oo).This study showed that the levels of glutathione peroxidase (a biological stress marker) were lower in recurrent aphthous stomatitis patients than in control subjects.
Conclusion: Serum enzymatic antioxidant levels were lower in recurrent aphthous stomatitis patients as compared to controls, so oxidative stress plays an important role in the pathogenesis of disease. |
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| ISSN: | 1815-4018 2410-5422 |