Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients
Objective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients. Study Design: This was a case control study. Place and Duration of Study: The study was conducted in biochemistry department of Islamic International Medical Colle...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Riphah International University, Islamabad
2021-11-01
|
| Series: | Journal of Islamic International Medical College |
| Subjects: | |
| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1044 |
| _version_ | 1811340600572641280 |
|---|---|
| author | Rabbia Shabbir, Amena Rahim, Muhammad Afzal |
| author_facet | Rabbia Shabbir, Amena Rahim, Muhammad Afzal |
| author_sort | Rabbia Shabbir, Amena Rahim, Muhammad Afzal |
| collection | DOAJ |
| description | Objective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients.
Study Design: This was a case control study.
Place and Duration of Study: The study was conducted in biochemistry department of Islamic International Medical College- Trust (IIMC-T) Rawalpindi from 15 March 2016 to 14 March 2017.
Materials and Methods: The study included 160 subjects divided into two groups Aphthous group and Non- Aphthous group. Aphthous group comprised of 70 recurrent aphthous stomatitis patients with active lesion and 90 age and sex matched healthy controls were included in the non-aphthous group .From all the participants 2 ml of blood was taken. Serum glutathione peroxidase levels were measured using enzyme linked immunosorbent assay technique. This ELISA kit uses Sandwich-ELISA as the method.
Results: The comparison of mean of serum glutathione peroxidase levels between aphthous and non-aphthous group was significant (p<o.oo).This study showed that the levels of glutathione peroxidase (a biological stress marker) were lower in recurrent aphthous stomatitis patients than in control subjects.
Conclusion: Serum enzymatic antioxidant levels were lower in recurrent aphthous stomatitis patients as compared to controls, so oxidative stress plays an important role in the pathogenesis of disease. |
| first_indexed | 2024-04-13T18:44:23Z |
| format | Article |
| id | doaj.art-5613219dcbb2455b80ca6fbadac5b2fe |
| institution | Directory Open Access Journal |
| issn | 1815-4018 2410-5422 |
| language | English |
| last_indexed | 2024-04-13T18:44:23Z |
| publishDate | 2021-11-01 |
| publisher | Riphah International University, Islamabad |
| record_format | Article |
| series | Journal of Islamic International Medical College |
| spelling | doaj.art-5613219dcbb2455b80ca6fbadac5b2fe2022-12-22T02:34:38ZengRiphah International University, IslamabadJournal of Islamic International Medical College1815-40182410-54222021-11-011331331361440Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis PatientsRabbia Shabbir, Amena Rahim, Muhammad AfzalObjective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients. Study Design: This was a case control study. Place and Duration of Study: The study was conducted in biochemistry department of Islamic International Medical College- Trust (IIMC-T) Rawalpindi from 15 March 2016 to 14 March 2017. Materials and Methods: The study included 160 subjects divided into two groups Aphthous group and Non- Aphthous group. Aphthous group comprised of 70 recurrent aphthous stomatitis patients with active lesion and 90 age and sex matched healthy controls were included in the non-aphthous group .From all the participants 2 ml of blood was taken. Serum glutathione peroxidase levels were measured using enzyme linked immunosorbent assay technique. This ELISA kit uses Sandwich-ELISA as the method. Results: The comparison of mean of serum glutathione peroxidase levels between aphthous and non-aphthous group was significant (p<o.oo).This study showed that the levels of glutathione peroxidase (a biological stress marker) were lower in recurrent aphthous stomatitis patients than in control subjects. Conclusion: Serum enzymatic antioxidant levels were lower in recurrent aphthous stomatitis patients as compared to controls, so oxidative stress plays an important role in the pathogenesis of disease.https://journals.riphah.edu.pk/index.php/jiimc/article/view/1044glutathione peroxidase, oxidative stress, recurrent aphthous stomatitis |
| spellingShingle | Rabbia Shabbir, Amena Rahim, Muhammad Afzal Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients Journal of Islamic International Medical College glutathione peroxidase, oxidative stress, recurrent aphthous stomatitis |
| title | Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients |
| title_full | Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients |
| title_fullStr | Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients |
| title_full_unstemmed | Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients |
| title_short | Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis Patients |
| title_sort | assessment of serum enzymatic antioxidant levels in recurrent aphthous stomatitis patients |
| topic | glutathione peroxidase, oxidative stress, recurrent aphthous stomatitis |
| url | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1044 |
| work_keys_str_mv | AT rabbiashabbiramenarahimmuhammadafzal assessmentofserumenzymaticantioxidantlevelsinrecurrentaphthousstomatitispatients |