Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impair immune cell functions and promote tumor progression. Mounting evidence indicates that cytokines and chemokines in the tumor microenvironment alter MDSCs. Various cytokines and chemokines are involved in MDSC production,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/5/1236 |
| _version_ | 1797475473776705536 |
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| author | Ru Li Mousumi Beto Mukherjee Jun Lin |
| author_facet | Ru Li Mousumi Beto Mukherjee Jun Lin |
| author_sort | Ru Li |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impair immune cell functions and promote tumor progression. Mounting evidence indicates that cytokines and chemokines in the tumor microenvironment alter MDSCs. Various cytokines and chemokines are involved in MDSC production, their infiltration into tumors, and their exertion of suppressive functions. Here, we consider those cytokines, chemokines, and MDSCs as an intricately connected, complex system and we focus on how tumors manipulate the MDSCs through various cytokines and chemokines. We also discuss treatment capitalizing on cytokines/chemokine signaling aimed at combating the potent immunosuppressive activities of MDSCs to improve disease outcomes. |
| first_indexed | 2024-03-09T20:45:36Z |
| format | Article |
| id | doaj.art-561404c389b84c7384eb9ab733ee882b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:45:36Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-561404c389b84c7384eb9ab733ee882b2023-11-23T22:47:58ZengMDPI AGCancers2072-66942022-02-01145123610.3390/cancers14051236Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and ChemokinesRu Li0Mousumi Beto Mukherjee1Jun Lin2Department of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USADepartment of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USADepartment of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USAMyeloid-derived suppressor cells (MDSCs) are immature myeloid cells that impair immune cell functions and promote tumor progression. Mounting evidence indicates that cytokines and chemokines in the tumor microenvironment alter MDSCs. Various cytokines and chemokines are involved in MDSC production, their infiltration into tumors, and their exertion of suppressive functions. Here, we consider those cytokines, chemokines, and MDSCs as an intricately connected, complex system and we focus on how tumors manipulate the MDSCs through various cytokines and chemokines. We also discuss treatment capitalizing on cytokines/chemokine signaling aimed at combating the potent immunosuppressive activities of MDSCs to improve disease outcomes.https://www.mdpi.com/2072-6694/14/5/1236myeloid-derived suppressor cellscytokineschemokinescancer metastasis |
| spellingShingle | Ru Li Mousumi Beto Mukherjee Jun Lin Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines Cancers myeloid-derived suppressor cells cytokines chemokines cancer metastasis |
| title | Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines |
| title_full | Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines |
| title_fullStr | Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines |
| title_full_unstemmed | Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines |
| title_short | Coordinated Regulation of Myeloid-Derived Suppressor Cells by Cytokines and Chemokines |
| title_sort | coordinated regulation of myeloid derived suppressor cells by cytokines and chemokines |
| topic | myeloid-derived suppressor cells cytokines chemokines cancer metastasis |
| url | https://www.mdpi.com/2072-6694/14/5/1236 |
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