Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study
Maternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with...
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/4039 |
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| author | Anne Gaml-Sørensen Nis Brix Lea Lykke Harrits Lunddorf Andreas Ernst Birgit Bjerre Høyer Gunnar Toft Tine Brink Henriksen Cecilia Høst Ramlau-Hansen |
| author_facet | Anne Gaml-Sørensen Nis Brix Lea Lykke Harrits Lunddorf Andreas Ernst Birgit Bjerre Høyer Gunnar Toft Tine Brink Henriksen Cecilia Høst Ramlau-Hansen |
| author_sort | Anne Gaml-Sørensen |
| collection | DOAJ |
| description | Maternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with pubertal timing in boys and girls. Information on maternal intake of vitamin D supplements was obtained by self-report in mid-pregnancy. Self-reported information on the current status of various pubertal milestones was obtained every six months throughout puberty. Mean differences in months at attaining each pubertal milestone and an average estimate for the mean difference in attaining all pubertal milestones were estimated according to maternal intake of vitamin D supplements using multivariable interval-censored regression models. Lower maternal intake of vitamin D supplements was associated with later pubertal timing in boys. For the average estimate, boys had 0.5 months (95% CI 0.1; 0.9) later pubertal timing per 5 µg/day lower maternal vitamin D supplement intake. Maternal intake of vitamin D supplements was not associated with pubertal timing in girls. Spline plots and sensitivity analyses supported the findings. Whether the observed association with boys’ pubertal timing translates into an increased risk of disease in adulthood is unknown. |
| first_indexed | 2024-03-10T22:19:17Z |
| format | Article |
| id | doaj.art-5615e0e8cbdd4a8a909e4886e8dbc361 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:19:17Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5615e0e8cbdd4a8a909e4886e8dbc3612023-11-19T12:19:30ZengMDPI AGNutrients2072-66432023-09-011518403910.3390/nu15184039Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up StudyAnne Gaml-Sørensen0Nis Brix1Lea Lykke Harrits Lunddorf2Andreas Ernst3Birgit Bjerre Høyer4Gunnar Toft5Tine Brink Henriksen6Cecilia Høst Ramlau-Hansen7Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, DenmarkOpen Patient Data Explorative Network, Odense University Hospital, 5000 Odense, DenmarkSteno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus N, DenmarkDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus N, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, DenmarkMaternal vitamin D may be important for several organ systems in the offspring, including the reproductive system. In this population-based follow-up study of 12,991 Danish boys and girls born 2000–2003, we investigated if maternal intake of vitamin D supplements during pregnancy was associated with pubertal timing in boys and girls. Information on maternal intake of vitamin D supplements was obtained by self-report in mid-pregnancy. Self-reported information on the current status of various pubertal milestones was obtained every six months throughout puberty. Mean differences in months at attaining each pubertal milestone and an average estimate for the mean difference in attaining all pubertal milestones were estimated according to maternal intake of vitamin D supplements using multivariable interval-censored regression models. Lower maternal intake of vitamin D supplements was associated with later pubertal timing in boys. For the average estimate, boys had 0.5 months (95% CI 0.1; 0.9) later pubertal timing per 5 µg/day lower maternal vitamin D supplement intake. Maternal intake of vitamin D supplements was not associated with pubertal timing in girls. Spline plots and sensitivity analyses supported the findings. Whether the observed association with boys’ pubertal timing translates into an increased risk of disease in adulthood is unknown.https://www.mdpi.com/2072-6643/15/18/4039Vitamin Dmicronutrientprenatal exposuresreproductive development |
| spellingShingle | Anne Gaml-Sørensen Nis Brix Lea Lykke Harrits Lunddorf Andreas Ernst Birgit Bjerre Høyer Gunnar Toft Tine Brink Henriksen Cecilia Høst Ramlau-Hansen Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study Nutrients Vitamin D micronutrient prenatal exposures reproductive development |
| title | Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study |
| title_full | Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study |
| title_fullStr | Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study |
| title_full_unstemmed | Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study |
| title_short | Maternal Intake of Vitamin D Supplements during Pregnancy and Pubertal Timing in Children: A Population-Based Follow-Up Study |
| title_sort | maternal intake of vitamin d supplements during pregnancy and pubertal timing in children a population based follow up study |
| topic | Vitamin D micronutrient prenatal exposures reproductive development |
| url | https://www.mdpi.com/2072-6643/15/18/4039 |
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