Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study.
<h4>Purpose</h4>To investigate the association between the characteristics of the retinal vascular network in the elderly and retinal nerve fiber layer (RNFL) thickness in a population-based study.<h4>Methods</h4>We conducted a population-based study, the Montrachet study (Ma...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0241055 |
| _version_ | 1818965489295032320 |
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| author | Louis Arnould Martin Guillemin Alassane Seydou Pierre-Henry Gabrielle Abderrahmane Bourredjem Ryo Kawasaki Christine Binquet Alain M Bron Catherine Creuzot-Garcher |
| author_facet | Louis Arnould Martin Guillemin Alassane Seydou Pierre-Henry Gabrielle Abderrahmane Bourredjem Ryo Kawasaki Christine Binquet Alain M Bron Catherine Creuzot-Garcher |
| author_sort | Louis Arnould |
| collection | DOAJ |
| description | <h4>Purpose</h4>To investigate the association between the characteristics of the retinal vascular network in the elderly and retinal nerve fiber layer (RNFL) thickness in a population-based study.<h4>Methods</h4>We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease), in participants aged ≥ 75 years. RNFL thickness was assessed with spectral-domain optical coherence tomography (SD-OCT). Analysis of the retinal vascular network was performed by means of the Singapore "I" Vessel Assessment (SIVA) software based on fundus photography.<h4>Results</h4>Data from 970 participants were suitable for analysis. Patients with optic neuropathy were excluded. In multivariable analysis, each standard deviation (SD) decrease in the caliber of the six largest arterioles and veins in zone B and the six largest arterioles and veins in zone C was associated with a decrease in global RNFL thickness (β = -1.62 μm, P = 0.001; β = -2.39 μm, P < 0.001; β = -1.56 μm, P = 0.002; and β = -2.64 μm, P < 0.001, respectively).<h4>Conclusions</h4>Our study found that decreased retinal vessels caliber were associated with a decreased RNFL thickness in the elderly without optic neuropathy. |
| first_indexed | 2024-12-20T13:17:49Z |
| format | Article |
| id | doaj.art-56162f1f0cdc4d70a47dad2b5ff5fdc3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T13:17:49Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-56162f1f0cdc4d70a47dad2b5ff5fdc32022-12-21T19:39:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024105510.1371/journal.pone.0241055Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study.Louis ArnouldMartin GuilleminAlassane SeydouPierre-Henry GabrielleAbderrahmane BourredjemRyo KawasakiChristine BinquetAlain M BronCatherine Creuzot-Garcher<h4>Purpose</h4>To investigate the association between the characteristics of the retinal vascular network in the elderly and retinal nerve fiber layer (RNFL) thickness in a population-based study.<h4>Methods</h4>We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease), in participants aged ≥ 75 years. RNFL thickness was assessed with spectral-domain optical coherence tomography (SD-OCT). Analysis of the retinal vascular network was performed by means of the Singapore "I" Vessel Assessment (SIVA) software based on fundus photography.<h4>Results</h4>Data from 970 participants were suitable for analysis. Patients with optic neuropathy were excluded. In multivariable analysis, each standard deviation (SD) decrease in the caliber of the six largest arterioles and veins in zone B and the six largest arterioles and veins in zone C was associated with a decrease in global RNFL thickness (β = -1.62 μm, P = 0.001; β = -2.39 μm, P < 0.001; β = -1.56 μm, P = 0.002; and β = -2.64 μm, P < 0.001, respectively).<h4>Conclusions</h4>Our study found that decreased retinal vessels caliber were associated with a decreased RNFL thickness in the elderly without optic neuropathy.https://doi.org/10.1371/journal.pone.0241055 |
| spellingShingle | Louis Arnould Martin Guillemin Alassane Seydou Pierre-Henry Gabrielle Abderrahmane Bourredjem Ryo Kawasaki Christine Binquet Alain M Bron Catherine Creuzot-Garcher Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. PLoS ONE |
| title | Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. |
| title_full | Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. |
| title_fullStr | Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. |
| title_full_unstemmed | Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. |
| title_short | Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study. |
| title_sort | association between the retinal vascular network and retinal nerve fiber layer in the elderly the montrachet study |
| url | https://doi.org/10.1371/journal.pone.0241055 |
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