Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (strok...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402032675X |
| _version_ | 1818958986567745536 |
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| author | Masahito Nakazaki Shinichi Oka Masanori Sasaki Yuko Kataoka-Sasaki Hiroshi Nagahama Kazuo Hashi Jeffery D. Kocsis Osamu Honmou |
| author_facet | Masahito Nakazaki Shinichi Oka Masanori Sasaki Yuko Kataoka-Sasaki Hiroshi Nagahama Kazuo Hashi Jeffery D. Kocsis Osamu Honmou |
| author_sort | Masahito Nakazaki |
| collection | DOAJ |
| description | Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (stroke prone) rat model in which organs including kidney, brain, heart and liver are damaged during aging due to spontaneous hypertension. Gene expression analysis indicated that infused MSCs activates transforming growth factor-β1-smad3/forkhead box O1 signaling pathway. Renal dysfunction was recovered after MSC infusion. Collectively, intravenous infusion of MSC may extend lifespan in this model system. |
| first_indexed | 2024-12-20T11:34:28Z |
| format | Article |
| id | doaj.art-5616ed1cb1b848d8bd07d8ef188ff84d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-20T11:34:28Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-5616ed1cb1b848d8bd07d8ef188ff84d2022-12-21T19:42:09ZengElsevierHeliyon2405-84402020-12-01612e05833Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cellsMasahito Nakazaki0Shinichi Oka1Masanori Sasaki2Yuko Kataoka-Sasaki3Hiroshi Nagahama4Kazuo Hashi5Jeffery D. Kocsis6Osamu Honmou7Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, 06516, USADepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, JapanDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, 06516, USA; Corresponding author.Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, JapanDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, JapanDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, JapanDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, 06516, USADepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, 06516, USAIntravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (stroke prone) rat model in which organs including kidney, brain, heart and liver are damaged during aging due to spontaneous hypertension. Gene expression analysis indicated that infused MSCs activates transforming growth factor-β1-smad3/forkhead box O1 signaling pathway. Renal dysfunction was recovered after MSC infusion. Collectively, intravenous infusion of MSC may extend lifespan in this model system.http://www.sciencedirect.com/science/article/pii/S240584402032675XMesenchymal stem cellCellular therapyLifespan |
| spellingShingle | Masahito Nakazaki Shinichi Oka Masanori Sasaki Yuko Kataoka-Sasaki Hiroshi Nagahama Kazuo Hashi Jeffery D. Kocsis Osamu Honmou Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells Heliyon Mesenchymal stem cell Cellular therapy Lifespan |
| title | Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells |
| title_full | Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells |
| title_fullStr | Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells |
| title_full_unstemmed | Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells |
| title_short | Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells |
| title_sort | prolonged lifespan in a spontaneously hypertensive rat stroke prone model following intravenous infusion of mesenchymal stem cells |
| topic | Mesenchymal stem cell Cellular therapy Lifespan |
| url | http://www.sciencedirect.com/science/article/pii/S240584402032675X |
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