The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model
It was aimed to investigate the utility of different fluid replacement therapies in the acute phase of a combined experimental traumatic brain injury and hemorrhagic shock model in terms of biochemical, hemostatic and pathological changes in the brain. 48 rats were divided up into 6 groups (n=8). Co...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2021-09-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=117785 |
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| author | Mustafa Safa Pepele Neslihan Yucel Mustafa Namik Oztanir Nese Karadag Soylu Ali Alper Takmaz Fatma Ozyalin |
| author_facet | Mustafa Safa Pepele Neslihan Yucel Mustafa Namik Oztanir Nese Karadag Soylu Ali Alper Takmaz Fatma Ozyalin |
| author_sort | Mustafa Safa Pepele |
| collection | DOAJ |
| description | It was aimed to investigate the utility of different fluid replacement therapies in the acute phase of a combined experimental traumatic brain injury and hemorrhagic shock model in terms of biochemical, hemostatic and pathological changes in the brain. 48 rats were divided up into 6 groups (n=8). Control group (S) rats were subjected to sham experimental hemorrhagic shock after which they underwent a sham operation, while trauma group (T) rats were subjected to hemorrhagic shock and subsequent head trauma with no treatment. Among the rats subjected to hemorrhagic shock and subsequent head trauma, those given 3% NaCl after this were named as HS group; those given HyperHeas [7.2% NaCl / 6% poly (O-2-Hydroxyethyl) starch] were named as HyperHS group; those given 0.9% NaCl were determined as NS group and those given ringer lactate as RL group. 24-hours later, the fluids effects were evaluated. The brain fluid content and INR levels were significantly higher in all the experimental groups when set against those in the NS group (p ranged [Med-Science 2021; 10(3.000): 725-31] |
| first_indexed | 2024-03-08T07:01:40Z |
| format | Article |
| id | doaj.art-56171b997d9a4d2e9df50a5b3bd76255 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T07:01:40Z |
| publishDate | 2021-09-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-56171b997d9a4d2e9df50a5b3bd762552024-02-03T05:37:10ZengSociety of Turaz BilimMedicine Science2147-06342021-09-011037253110.5455/medscience.2020.12.261117785The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat modelMustafa Safa Pepele0Neslihan Yucel1Mustafa Namik Oztanir2Nese Karadag Soylu3Ali Alper Takmaz4Fatma Ozyalin5Department of Emergency Medicine, Malatya Turgut Ozal University, School of Medicine, Malatya, Turkey Inonu University Medical Faculty Emergency Medicine Department Department of Neurosurgery, Bezmialem Foundation University, School of Medicine, Istanbul, Turkey Department of Pathology,Inonu University, School of Medicine, Malatya, Turkey Department of Neurosurgery, Malatya Training and Research Hospital, Malatya, Turkey Department of Biochemistry, Turgut Ozal University, School of Medicine, Malatya, TurkeyIt was aimed to investigate the utility of different fluid replacement therapies in the acute phase of a combined experimental traumatic brain injury and hemorrhagic shock model in terms of biochemical, hemostatic and pathological changes in the brain. 48 rats were divided up into 6 groups (n=8). Control group (S) rats were subjected to sham experimental hemorrhagic shock after which they underwent a sham operation, while trauma group (T) rats were subjected to hemorrhagic shock and subsequent head trauma with no treatment. Among the rats subjected to hemorrhagic shock and subsequent head trauma, those given 3% NaCl after this were named as HS group; those given HyperHeas [7.2% NaCl / 6% poly (O-2-Hydroxyethyl) starch] were named as HyperHS group; those given 0.9% NaCl were determined as NS group and those given ringer lactate as RL group. 24-hours later, the fluids effects were evaluated. The brain fluid content and INR levels were significantly higher in all the experimental groups when set against those in the NS group (p ranged [Med-Science 2021; 10(3.000): 725-31]http://www.ejmanager.com/fulltextpdf.php?mno=117785traumatic brain injuryhemorrhagic shockratsfluid resuscitation |
| spellingShingle | Mustafa Safa Pepele Neslihan Yucel Mustafa Namik Oztanir Nese Karadag Soylu Ali Alper Takmaz Fatma Ozyalin The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model Medicine Science traumatic brain injury hemorrhagic shock rats fluid resuscitation |
| title | The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| title_full | The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| title_fullStr | The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| title_full_unstemmed | The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| title_short | The effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| title_sort | effects of different fluid resuscitations in the acute phase of combined traumatic brain injury and hemorrhagic shock in an experimental rat model |
| topic | traumatic brain injury hemorrhagic shock rats fluid resuscitation |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=117785 |
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